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Slc15a1 Gene Detail
Summary
  • Symbol
    Slc15a1
  • Name
    solute carrier family 15 (oligopeptide transporter), member 1
  • Synonyms
    PECT1, PEPT1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861376
    NCBI Gene: 56643
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:121697033-121742664 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 65.26 cM, cytoband E5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1709 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861376
 protein coding gene Chr14:121697033-121742666 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021662
 protein coding gene Chr14:119274466-119323581 (-)
A/J MGP_AJ_G0021622
 protein coding gene Chr14:114667073-114714239 (-)
AKR/J MGP_AKRJ_G0021598
 protein coding gene Chr14:118372771-118427679 (-)
BALB/cJ MGP_BALBcJ_G0021628
 protein coding gene Chr14:115204756-115255957 (-)
C3H/HeJ MGP_C3HHeJ_G0021406
 protein coding gene Chr14:118268305-118320945 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022068
 protein coding gene Chr14:123868084-123922506 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019606
 protein coding gene Chr14:110559357-110603878 (-)
CAST/EiJ MGP_CASTEiJ_G0020921
 protein coding gene Chr14:116163355-116217482 (-)
CBA/J MGP_CBAJ_G0021374
 protein coding gene Chr14:128593715-128650880 (-)
DBA/2J MGP_DBA2J_G0021497
 protein coding gene Chr14:114538467-114585466 (-)
FVB/NJ MGP_FVBNJ_G0021475
 protein coding gene Chr14:112871747-112919204 (-)
LP/J MGP_LPJ_G0021565
 protein coding gene Chr14:120216898-120263363 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021502
 protein coding gene Chr14:133600022-133658656 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022091
 protein coding gene Chr14:117938497-117984253 (-)
PWK/PhJ MGP_PWKPhJ_G0020665
 protein coding gene Chr14:111580998-111631221 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020503
 protein coding gene Chr14:114137675-114182072 (-)
WSB/EiJ MGP_WSBEiJ_G0020977
 protein coding gene Chr14:118638051-118694462 (-)



Homology
more
  • Human Ortholog
    SLC15A1, solute carrier family 15 member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC15A1, solute carrier family 15 member 1
  • Synonyms
    HPECT1, HPEPT1, PEPT1
  • Links
    NCBI Gene ID: 6564
    neXtProt AC: NX_P46059
    UniProt: P46059

  • Chr Location
    13q32.2-q32.3; chr13:98683801-98752672 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Peptide uptake in the intestine is substantially reduced in mice homozygous for a null mutation of this gene.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    6
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025557 Ensembl Gene Model | MGI Sequence Detail 45632 C57BL/6J ±  kb
transcript ENSMUST00000088386 Ensembl | MGI Sequence Detail 3121 Not Applicable  
polypeptide ENSMUSP00000085728 Ensembl | MGI Sequence Detail 709 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    Genomic 2
    cDNA 7

    Microarray probesets 2
References
more
  • Summaries
    All 55
    Developmental Gene Expression 2
    Gene Ontology 10
    Phenotypes 22
  • Earliest
    J:62996 Fei Y, et al., cDNA structure, genomic organization, and promoter analysis of the mouse intestinal peptide transporter PEPT1. Biochim Biophys Acta. 2000 Jun 21;1492(1):145-54
  • Latest
    J:331214 Sung J, et al., PepT1-knockout mice harbor a protective metabolome beneficial for intestinal wound healing. Am J Physiol Gastrointest Liver Physiol. 2021 May 1;320(5):G888-G896
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory