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Sphk2 Gene Detail
Summary
  • Symbol
    Sphk2
  • Name
    sphingosine kinase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1861380
    NCBI Gene: 56632
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45358891-45367426 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.45 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    261 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1861380
 protein coding gene Chr7:45358887-45367426 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032242
 protein coding gene Chr7:46018028-46026535 (-)
A/J MGP_AJ_G0032221
 protein coding gene Chr7:45105437-45113972 (-)
AKR/J MGP_AKRJ_G0032157
 protein coding gene Chr7:46357534-46366072 (-)
BALB/cJ MGP_BALBcJ_G0032233
 protein coding gene Chr7:45100185-45108721 (-)
C3H/HeJ MGP_C3HHeJ_G0031948
 protein coding gene Chr7:46851789-46860325 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032725
 protein coding gene Chr7:48268646-48277189 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029739
 protein coding gene Chr7:47659506-47667971 (-)
CAST/EiJ MGP_CASTEiJ_G0031277
 protein coding gene Chr7:38292052-38300591 (-)
CBA/J MGP_CBAJ_G0031913
 protein coding gene Chr7:49878401-49886981 (-)
DBA/2J MGP_DBA2J_G0032071
 protein coding gene Chr7:44786059-44794571 (-)
FVB/NJ MGP_FVBNJ_G0032022
 protein coding gene Chr7:44558747-44567291 (-)
LP/J MGP_LPJ_G0032149
 protein coding gene Chr7:46722693-46731226 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032059
 protein coding gene Chr7:48559371-48567961 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032741
 protein coding gene Chr7:45568762-45577298 (-)
PWK/PhJ MGP_PWKPhJ_G0030999
 protein coding gene Chr7:38152976-38161519 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030837
 protein coding gene Chr7:33599542-33609549 (-)
WSB/EiJ MGP_WSBEiJ_G0031394
 protein coding gene Chr7:46073045-46081581 (-)



Homology
more
  • Human Ortholog
    SPHK2, sphingosine kinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPHK2, sphingosine kinase 2
  • Synonyms
    SK 2, SK-2, SPK 2, SPK-2
  • Links
    NCBI Gene ID: 56848
    neXtProt AC: NX_Q9NRA0
    UniProt: Q9NRA0

  • Chr Location
    19q13.33; chr19:48619291-48630717 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 4 alleles in 4 genetic backgrounds
    35 phenotypes from multigenic genotypes
    2 images
    101 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    72
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    873
  • Tissues
    165
  • cDNA Data
    15
  • Literature Summary
    13
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000057342 Ensembl Gene Model | MGI Sequence Detail 8536 C57BL/6J ±  kb
transcript ENSMUST00000107737 Ensembl | MGI Sequence Detail 3548 Not Applicable  
polypeptide ENSMUSP00000103366 Ensembl | MGI Sequence Detail 617 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    cDNA 16
    Primer pair 4

    Microarray probesets 4
Other
Accession IDs
less
MGI:2142309
References
more
  • Summaries
    All 161
    Developmental Gene Expression 13
    Gene Ontology 16
    Phenotypes 101
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:352028 Green CD, et al., Sphingosine kinase 2 and p62 regulation are determinants of sexual dimorphism in hepatocellular carcinoma. Mol Metab. 2024 Aug;86:101971
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory