Gsk3b MGI Mouse Gene Detail - MGI:1861437 - glycogen synthase kinase 3 beta

Symbol

Gsk3b
Name

glycogen synthase kinase 3 beta
Synonyms

7330414F15Rik, 8430431H08Rik, GSK-3, GSK3, GSK-3beta

Feature Type

protein coding gene
IDs

MGI:1861437
NCBI Gene: 56637
Alliance

gene page
Transcription Start Sites

21 TSS

Sequence Map

Chr16:37909363-38066446 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 26.54 cM, cytoband B4
Mapping Data

3 experiments

SNPs within 2kb

3303 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1861437	protein coding gene	Chr16:37909363-38066446 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022808	protein coding gene	Chr16:36600728-36762245 (+)
A/J	MGP_AJ_G0022773	protein coding gene	Chr16:34772561-34940629 (+)
AKR/J	MGP_AKRJ_G0022745	protein coding gene	Chr16:36106772-36271509 (+)
BALB/cJ	MGP_BALBcJ_G0022774	protein coding gene	Chr16:34895586-35053605 (+)
C3H/HeJ	MGP_C3HHeJ_G0022538	protein coding gene	Chr16:36209593-36370484 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023221	protein coding gene	Chr16:37445514-37602467 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020736	protein coding gene	Chr16:35163242-35316158 (+)
CAST/EiJ	MGP_CASTEiJ_G0022064	protein coding gene	Chr16:36356603-36521980 (+)
CBA/J	MGP_CBAJ_G0022509	protein coding gene	Chr16:39079613-39254184 (+)
DBA/2J	MGP_DBA2J_G0022641	protein coding gene	Chr16:34664711-34822284 (+)
FVB/NJ	MGP_FVBNJ_G0022616	protein coding gene	Chr16:34696009-34853399 (+)
LP/J	MGP_LPJ_G0022709	protein coding gene	Chr16:36284590-36446253 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022635	protein coding gene	Chr16:38208140-38372434 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023236	protein coding gene	Chr16:36060391-36229152 (+)
PWK/PhJ	MGP_PWKPhJ_G0021804	protein coding gene	Chr16:35072282-35233873 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021635	protein coding gene	Chr16:35973760-36126601 (+)
WSB/EiJ	MGP_WSBEiJ_G0022108	protein coding gene	Chr16:36137717-36299947 (+)

Human Ortholog

GSK3B, glycogen synthase kinase 3 beta

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GSK3B, glycogen synthase kinase 3 beta
Links

HGNC:4617

NCBI Gene ID: 2932

neXtProt AC: NX_P49841

UniProt: P49841
Chr Location

3q13.33; chr3:119821321-120094994 (-) GRCh38

MGI Vertebrate Homology

Gsk3b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GSK3B
Gene Tree

Gsk3b

Diseases

5 with human GSK3B associations

				Human Disease	Mouse Models
				Alzheimer's disease IDs Alzheimer's disease DOID:10652 ICD10CM:G30 ICD9CM:331.0 KEGG:05010 MESH:D000544 NCI:C2866 UMLS_CUI:C0002395
				amyotrophic lateral sclerosis IDs amyotrophic lateral sclerosis DOID:332 ICD10CM:G12.21 ICD9CM:335.20 KEGG:05014 MESH:D000690 NCI:C34373 OMIM:PS105400 ORDO:803 UMLS_CUI:C0002736
				bipolar disorder IDs bipolar disorder DOID:3312 DOID:3311 DOID:9554 DOID:9555 ICD10CM:F31 ICD9CM:296.40 ICD9CM:296.60 ICD9CM:296.80 MESH:D001714 NCI:C34423 NCI:C34424 NCI:C34805 UMLS_CUI:C0005586 UMLS_CUI:C0005587 UMLS_CUI:C0024713 UMLS_CUI:C0236780
				oral squamous cell carcinoma IDs oral squamous cell carcinoma DOID:0050866
				schizophrenia IDs schizophrenia DOID:5419 DOID:14734 ICD10CM:F20 ICD9CM:295 ICD9CM:295.8 ICD9CM:295.80 ICD9CM:295.9 ICD9CM:295.90 MESH:D012559 NCI:C3362 OMIM:181500 UMLS_CUI:C0036341

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

51 phenotypes from 9 alleles in 15 genetic backgrounds
37 phenotypes from multigenic genotypes
2 images
170 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

124
Endonuclease-mediated

6
Gene trapped

74
Targeted

15
Transgenic

29
Genomic Mutations

2 involving Gsk3b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

113 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene may die embryonically around mid-gestation or neonatally. When mice die neonatally, cleft palate and sternum are present.

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All GO Annotations

293
GO References

74

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1371
Tissues

232
cDNA Data

19
Literature Summary

133

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gsk3b

ZFIN gsk3ba

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All Sequences

63
RefSeq

6
UniProt

5
CCDS

CCDS28163.1, CCDS84232.1

Ensembl

ENSMUSG00000022812 (Evidence)
NCBI Gene

56637

			Length	Strain/Species	Flank
genomic	56637	NCBI Gene Model \| MGI Sequence Detail	157084	C57BL/6J	± kb
transcript	NM_001347232	RefSeq \| MGI Sequence Detail	8342	C57BL/6
polypeptide	Q9WV60	UniProt \| EBI \| MGI Sequence Detail	420	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000008288 glycogen synthase kinase-3 beta

(term hierarchy)
PDB

4NU1, 5AIR, 6AE3
EC

2.7.11.1, 2.7.11.26
InterPro Domains

IPR050591 Glycogen Synthase Kinase-3

IPR039192 Glycogen synthase kinase 3, catalytic domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

Q9WV60 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 31

cDNA 20

Primer pair 8

Other 3

Microarray probesets 7

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MGI:1914056, MGI:1925394, MGI:2146721

Summaries

All 653

Developmental Gene Expression 133

Gene Ontology 74

Phenotypes 170
Earliest

J:155370 Cohen JS, Provide fluoxetine information vital to clinicians. J Clin Psychiatry. 1995 Dec;56(12):591
Latest

J:347984 Naillat F, et al., Calcium signaling induces partial EMT and renal fibrosis in a Wnt4(mCherry) knock-in mouse model. Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21;1870(5):167180

TSS for Gsk3b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138352	Chr16:37909403-37909426 (+)	52 bp
Tssr138353	Chr16:37909433-37909465 (+)	86 bp
Tssr138354	Chr16:37909476-37909490 (+)	120 bp
Tssr138355	Chr16:37909687-37909717 (+)	339 bp
Tssr138356	Chr16:37909723-37909757 (+)	377 bp
Tssr138357	Chr16:37909843-37909898 (+)	508 bp
Tssr138358	Chr16:37910154-37910170 (+)	799 bp
Tssr138359	Chr16:37910323-37910344 (+)	971 bp
Tssr138360	Chr16:37924894-37924899 (+)	15,534 bp
Tssr138361	Chr16:37930096-37930100 (+)	20,735 bp
Tssr138362	Chr16:37948902-37948910 (+)	39,543 bp
Tssr138363	Chr16:37952361-37952398 (+)	43,017 bp
Tssr138364	Chr16:37952412-37952423 (+)	43,055 bp
Tssr138365	Chr16:37963658-37963674 (+)	54,303 bp
Tssr138366	Chr16:37963675-37963720 (+)	54,335 bp
Tssr138367	Chr16:37998066-37998070 (+)	88,705 bp
Tssr138368	Chr16:38040478-38040489 (+)	131,121 bp
Tssr138369	Chr16:38061184-38061202 (+)	151,830 bp
Tssr138370	Chr16:38064753-38064769 (+)	155,398 bp
Tssr138371	Chr16:38065308-38065318 (+)	155,950 bp
Tssr138372	Chr16:38065358-38065373 (+)	156,003 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24