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Dab1tm1Cpr
Targeted Allele Detail
Summary
Symbol: Dab1tm1Cpr
Name: disabled 1; targeted mutation 1, Jonathan A Cooper
MGI ID: MGI:1861918
Synonyms: Dab1-, Dab1 ko, mdab1-1
Gene: Dab1  Location: Chr4:103476556-104602041 bp, + strand  Genetic Position: Chr4, 47.79 cM
Alliance: Dab1tm1Cpr page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:43647
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin resistance cassette replaced a genomic fragment containing sequences encoding the first 47 amino acids of the PTB domain. Western blot analysis on brain lysates derived from homozygous mice demonstrated the absence of the protein. (J:43647)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 46 assay results
2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dab1 Mutation:  79 strains or lines available
References
Original:  J:43647 Howell BW, et al., Neuronal position in the developing brain is regulated by mouse disabled-1 [see comments]. Nature. 1997 Oct 16;389(6652):733-7
All:  37 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory