About   Help   FAQ
Epas1tm1Rus
Targeted Allele Detail
Summary
Symbol: Epas1tm1Rus
Name: endothelial PAS domain protein 1; targeted mutation 1, David W Russell
MGI ID: MGI:1861921
Synonyms: Epas1-, HIF2alphaLacZ
Gene: Epas1  Location: Chr17:87061292-87140838 bp, + strand  Genetic Position: Chr17, 56.9 cM
Alliance: Epas1tm1Rus page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:50964
Parent Cell Line:  JH1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation details: A lacZ gene was inserted and fused in-frame into exon 2, and was followed by a neomycin selection cassette. Western blot analysis indicated that the expression of wild-type transcript was eliminated from this allele. However, a beta-galactosidase fusion protein was expressed under the control of the endogenous promoter. (J:50964)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 30 assay results
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Epas1 Mutation:  66 strains or lines available
References
Original:  J:50964 Tian H, et al., The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development. Genes Dev. 1998 Nov 1;12(21):3320-4
All:  19 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory