Gck<tm1Efr> Targeted Allele Detail MGI Mouse (MGI:1861929)

Gck^tm1Efr
Targeted Allele Detail

Summary

Symbol:	Gck^tm1Efr
Name:	glucokinase; targeted mutation 1, Shimon Efrat
MGI ID:	MGI:1861929
Synonyms:	GK-
Gene:	Gck Location: Chr11:5850820-5900081 bp, - strand Genetic Position: Chr11, 3.88 cM
Alliance:	Gck^tm1Efr page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:28756
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A fragment of the gene spanning exon 2 was replaced by a neomycin resistance cassette, resulting in a deletion and a frame shift of the transcript. Mice heterozygous for the targeted mutation had a 37% reduction in glucose phosphorylation activity in islet homogenates and a 28% reduction of activity in liver compared with wild-type littermates. (J:28756)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Structures Affected by this Mutation:

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Gck Mutation:	63 strains or lines available

References

Original:	J:28756 Bali D, et al., Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene. J Biol Chem. 1995 Sep 15;270(37):21464-7
All:	2 reference(s)

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