Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm1Sor
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Philippe Soriano
MGI ID:	MGI:1861932
Synonyms:	Gt(ROSA)26Sor, Gt(ROSA)26Sortm1(LacZ)Cos, Gtrosa26tm1Sor, Gtrosa26tm/Sor, i-LacZ, loxP-Stop-loxP lacZ reporter, LSL-LacZ, R26-Cond-lacZ, R26-floxstop-lacZ, R26fslz, R26LacZ, R26-LNL-LacZ, R26R, R26R-lacZ, R26RLacZ, R26RZ, Rosa26 cre reporter, ROSA26fl, ROSA26-floxed Neo-LacZ, ROSA26-flox-STOP-flox-lacZ, ROSA26FSLacZ, Rosa26LacZ, ROSA26-LacZ, Rosa26-lacZ cre reporter, Rosa26-LacZloxP, ROSA26::LNL::LacZ, ROSA26-loxP, Rosa26loxP-STOP-lacZ, Rosa26-LoxSTOPLox-LacZ, Rosa26r-, ROSA26R, ROSA26Rflox, Rosa26R-lacZ, Rosa26RlacZ, Rosa26RLacZ, ROSA26Sortm1Sor, Rosa26stop-LacZ, ROSA26XneorXlacZ, Rosa2R, RosaLoxP, Rosa-LoxP-Stop-LoxP-LacZ, RS, STOP-lacZ
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm1Sor page

Germline Transmission:	Earliest citation of germline transmission: J:64292
Parent Cell Line:	AK7 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Targeted (Conditional ready, Reporter) Mutation:    Insertion   Mutation details: A targeting vector was designed from the original gene trap strain, ROSA beta-geo26, to include a splice acceptor sequence (SA), a neo expression cassette flanked by loxP sites, a lacZ gene, and a polyadenylation (bpA) sequence inserted at a unique Xba1 site approximately 300-bp 5' of the original gene-trap integration site. In addition, a triple polyadenylation sequence was added to the 3' end of the neo expression cassette to prevent transcriptional read-through. Presence of the floxed neo cassette prevents lacZ expression. When crossed with a cre transgenic strain, lacZ is expressed in all cells/tissue where Cre is expressed. (J:64292) Inheritance:    Not Specified

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

649 assay results 5 RNA-Seq or microarray experiment(s)

List all tumor models in MMHCdb carrying Gt(ROSA)26Sortm1Sor

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 7 strains available      Cell Lines: 1 line available
Carrying any Gt(ROSA)26Sor Mutation:	993 strains or lines available

Original:	J:64292 Soriano P, Generalized lacZ expression with the ROSA26 Cre reporter strain [letter]. Nat Genet. 1999 Jan;21(1):70-1
All:	2796 reference(s)