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Il12rb2tm1Jm
Targeted Allele Detail
Summary
Symbol: Il12rb2tm1Jm
Name: interleukin 12 receptor, beta 2; targeted mutation 1, Jeanne Magram
MGI ID: MGI:1861950
Synonyms: IL-12Rbeta2-, IL-12Rbeta2KO
Gene: Il12rb2  Location: Chr6:67268302-67353172 bp, - strand  Genetic Position: Chr6, 30.81 cM
Alliance: Il12rb2tm1Jm page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65891
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin resistance cassette replaced exons 2 and 3 of the gene, deleting the ATG translation initiation codon, the signal peptide, and the N-terminal immunoglobulin domain of the receptor. (J:65891)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Il12rb2 Mutation:  48 strains or lines available
References
Original:  J:65891 Wu Cy, et al., IL-12 receptor ss2 (IL-12Rss2)-deficient mice are defective in IL-12-mediated signaling despite the presence of high affinity IL-12 binding sites. J Immunol. 2000 Dec 1;165(11):6221-8
All:  76 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory