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Cd47tm1Fpl
Targeted Allele Detail
Summary
Symbol: Cd47tm1Fpl
Name: CD47 antigen (Rh-related antigen, integrin-associated signal transducer); targeted mutation 1, Frederik P Lindberg
MGI ID: MGI:1861955
Synonyms: CD47-, IAP-, Itgptm1Fpl
Gene: Cd47  Location: Chr16:49671691-49732799 bp, + strand  Genetic Position: Chr16, 31.23 cM
Alliance: Cd47tm1Fpl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:36489
Parent Cell Line:  AB2.1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1b-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details: A neomycin resistance cassette was inserted into exon 2 of the gene, which encodes the signal peptide cleavage site and the IgV domain. Monoclonal antibodies recognizing the Ig domain failed to detect any CD47 antigen on the surface of erythrocytes, bone marrow cells, or other cells including peripheral blood leukocytes, splenocytes, and fibroblasts from homozygous mutant mice. In addition, no antigen was detected in mutant erythrocyte lysates with polyclonal antisera to the NH2 or COOH-termini. (J:36489)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 20 assay results
In Structures Affected by this Mutation: 9 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Cd47 Mutation:  48 strains or lines available
References
Original:  J:36489 Lindberg FP, et al., Decreased resistance to bacterial infection and granulocyte defects in IAP-deficient mice. Science. 1996 Nov 1;274(5288):795-8
All:  112 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory