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Lyntm1Sor
Targeted Allele Detail
Summary
Symbol: Lyntm1Sor
Name: LYN proto-oncogene, Src family tyrosine kinase; targeted mutation 1, Philippe Soriano
MGI ID: MGI:1861966
Synonyms: Lyn-
Gene: Lyn  Location: Chr4:3676865-3791613 bp, + strand  Genetic Position: Chr4, 2.05 cM
Alliance: Lyntm1Sor page
Lupus-like autoimmune disease in Lyntm1Sor/Lyntm1Sor and Lyntm1.1Calo/Lyntm1.1Calo Top2aGt(PST14568)Mfgc/0 mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:42037
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin resistance cassette replaced exons 3 - 7 of the gene. No transcript for the targeted gene was detected on Northern blots from homozygous mutant mouse bone marrow cells. (J:42037, J:102647)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Lyn Mutation:  65 strains or lines available
References
Original:  J:42037 Chan VW, et al., Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity. 1997 Jul;7(1):69-81
All:  140 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory