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Ntrk1tm1Bbd
Targeted Allele Detail
Summary
Symbol: Ntrk1tm1Bbd
Name: neurotrophic tyrosine kinase, receptor, type 1; targeted mutation 1, Mariano Barbacid
MGI ID: MGI:1888374
Synonyms: trkA-, trkAK-, trkTK
Gene: Ntrk1  Location: Chr3:87685551-87702469 bp, - strand  Genetic Position: Chr3, 38.62 cM
Alliance: Ntrk1tm1Bbd page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:17194
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: Sequences encoding 51 amino acids of the kinase catalytic domain were replaced with a neomycin cassette. RNase protection analysis on tissues isolated from homozygous mutant mice failed to identify any Ntrk1 transcripts. (J:17194)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 7 assay results
In Structures Affected by this Mutation: 11 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ntrk1 Mutation:  62 strains or lines available
References
Original:  J:17194 Smeyne RJ, et al., Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene [see comments]. Nature. 1994 Mar 17;368(6468):246-9
All:  28 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory