Timp2<tm1Pds> Targeted Allele Detail MGI Mouse (MGI:1888708)

Timp2^tm1Pds
Targeted Allele Detail

Summary

Symbol:	Timp2^tm1Pds
Name:	tissue inhibitor of metalloproteinase 2; targeted mutation 1, Paul D Soloway
MGI ID:	MGI:1888708
Synonyms:	Timp2-, TIMP-2KO, TIMP2KO
Gene:	Timp2 Location: Chr11:118191887-118246237 bp, - strand Genetic Position: Chr11, 83.09 cM
Alliance:	Timp2^tm1Pds page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:64001
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Replacement of the first coding exon with a neomycin cassette. (J:64001)
Inheritance:		Recessive

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

22 assay results
2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Timp2 Mutation:	22 strains or lines available

References

Original:	J:64001 Wang Z, et al., TIMP-2 is required for efficient activation of proMMP-2 in vivo. J Biol Chem. 2000 Aug 25;275(34):26411-5
All:	26 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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