Prnp<tm1Cwe> Targeted Allele Detail MGI Mouse (MGI:1888773)

Prnp^tm1Cwe
Targeted Allele Detail

Summary

Symbol:	Prnp^tm1Cwe
Name:	prion protein; targeted mutation 1, Charles Weissmann
MGI ID:	MGI:1888773
Synonyms:	Prnp^-, Prn-p⁰, Prnp⁰, Prnp⁰ Zurich I, Prnp^tm1ZH1, Prnp^tm1Zrch, Prnp trn^1Zrch, PrnpZH1, PrP⁰, PrP^C-KO, PrP^C Zrch-1, Zrch 1 Prnp⁰, ZrchI Prnp-, Zrch Prnp⁰, Zurich line
Gene:	Prnp Location: Chr2:131751848-131780349 bp, + strand Genetic Position: Chr2, 64.07 cM
Alliance:	Prnp^tm1Cwe page

Tg(Prnp*S170N*N174T)1020Aag/0 Prnp^tm1Cwe/Prnp^tm1Cwe mice develop a lethal neurologic disease with lesions in the brain and muscle

Show the 3 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:472
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1⁺

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A 552 bp fragment of the coding region contained within exon 3 was replaced with a 1.1 kb cassette containing the TK promoter followed by the neomycin gene. (J:472, J:83401)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Expression

In Mice Carrying this Mutation:	50 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 37 strains available Cell Lines: 0 lines available
Carrying any Prnp Mutation:	142 strains or lines available

References

Original:	J:472 Bueler H, et al., Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein [see comments]. Nature. 1992 Apr 16;356(6370):577-82
All:	327 reference(s)

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