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Gsk3btm1Jrw
Targeted Allele Detail
Summary
Symbol: Gsk3btm1Jrw
Name: glycogen synthase kinase 3 beta; targeted mutation 1, James R Woodgett
MGI ID: MGI:1888887
Synonyms: gsk3b-, GSK-3beta-
Gene: Gsk3b  Location: Chr16:37909363-38066446 bp, + strand  Genetic Position: Chr16, 26.54 cM, cytoband B4
Alliance: Gsk3btm1Jrw page
Increased bone mass in Gsk3btm1Jrw/Gsk3b+ mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:63274
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details: A neomycin resistance cassette replaced an exon encoding the ATP-binding loop. Southern and Western blots of embryonic fibroblasts (E12.5) showed no detectable DNA and protein of the targeted gene, respectively. (J:63274)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 45 assay results
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gsk3b Mutation:  113 strains or lines available
References
Original:  J:63274 Hoeflich KP, et al., Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation [see comments]. Nature. 2000 Jul 6;406(6791):86-90
All:  35 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory