Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Cdkn1atm1Led
Name:	cyclin dependent kinase inhibitor 1A; targeted mutation 1, Philip Leder
MGI ID:	MGI:1888950
Synonyms:	p21-, p21Cip1, p21Cip1/Waf1 -, p21CIP1/WAF1
Gene:	Cdkn1a  Location: Chr17:29309953-29319696 bp, + strand  Genetic Position: Chr17, 15.12 cM
Alliance:	Cdkn1atm1Led page

Germline Transmission:	Earliest citation of germline transmission: J:28420
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     A PGK-neomycin resistance cassette replaced a 3kb sequence containing exon 2. (J:28420) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	33 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

List all tumor models in MMHCdb carrying Cdkn1atm1Led

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdkn1a Mutation:	63 strains or lines available

Original:	J:28420 Deng C, et al., Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell. 1995 Aug 25;82(4):675-84
All:	142 reference(s)