Chrna4<tm1Dra> Targeted Allele Detail MGI Mouse (MGI:1888964)

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Chrna4^tm1Dra
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Summary

Symbol:	Chrna4^tm1Dra
Name:	cholinergic receptor, nicotinic, alpha polypeptide 4; targeted mutation 1, John Drago
MGI ID:	MGI:1888964
Gene:	Chrna4 Location: Chr2:180664104-180685339 bp, - strand Genetic Position: Chr2, 103.54 cM
Alliance:	Chrna4^tm1Dra page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:64208
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutation:		Insertion
		A neomycin gene was inserted into the fifth exon. (J:64208)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available Cell Lines: 0 lines available
Carrying any Chrna4 Mutation:	44 strains or lines available

References

Original:	J:64208 Ross SA, et al., Phenotypic characterization of an alpha 4 neuronal nicotinic acetylcholine receptor subunit knock-out mouse. J Neurosci. 2000 Sep 1;20(17):6431-41
All:	11 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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