Ackr1tm1Scp
Targeted Allele Detail
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| Symbol: |
Ackr1tm1Scp |
| Name: |
atypical chemokine receptor 1 (Duffy blood group); targeted mutation 1, Stephen C Peiper |
| MGI ID: |
MGI:1888977 |
| Synonyms: |
DARC- |
| Gene: |
Ackr1 Location: Chr1:173159457-173161079 bp, - strand Genetic Position: Chr1, 80.33 cM
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| Alliance: |
Ackr1tm1Scp page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:64222
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| Parent Cell Line: |
E14TG2a (ES Cell)
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| Strain of Origin: |
129P2/OlaHsd
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Genomic sequences corresponding to part of intron 1 and 90 bp of intron 2 were replaced by a neomycin resistance cassette. RT-PCR analysis demonstrated that a nonfunctional message is produced from this allele in total RNA derived from spleen. Binding assays demonstrated a lack of functional protein in homozygous mice.
(J:64222)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Original: |
J:64222 Dawson TC, et al., Exaggerated response to endotoxin in mice lacking the duffy antigen/receptor for chemokines (DARC). Blood. 2000 Sep 1;96(5):1681-4 |
| All: |
19 reference(s) |
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Analysis Tools
