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Msln Gene Detail
Summary
  • Symbol
    Msln
  • Name
    mesothelin
  • Synonyms
    megakaryocyte potentiating factor, MPF
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888992
    NCBI Gene: 56047
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:25967587-25973352 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.85 cM, cytoband A3.3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    241 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888992
 protein coding gene Chr17:25967587-25973352 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023364
 protein coding gene Chr17:24843382-24849087 (-)
A/J MGP_AJ_G0023323
 protein coding gene Chr17:24120481-24126194 (-)
AKR/J MGP_AKRJ_G0023289
 protein coding gene Chr17:24224660-24230365 (-)
BALB/cJ MGP_BALBcJ_G0023328
 protein coding gene Chr17:24346382-24352087 (-)
C3H/HeJ MGP_C3HHeJ_G0023088
 protein coding gene Chr17:24609157-24614870 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023770
 protein coding gene Chr17:25894624-25900337 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021246
 protein coding gene Chr17:21581728-21587619 (-)
CAST/EiJ MGP_CASTEiJ_G0022590
 protein coding gene Chr17:24488320-24494053 (-)
CBA/J MGP_CBAJ_G0023063
 protein coding gene Chr17:26803692-26809405 (-)
DBA/2J MGP_DBA2J_G0023193
 protein coding gene Chr17:23721596-23727758 (-)
FVB/NJ MGP_FVBNJ_G0023163
 protein coding gene Chr17:23459899-23465612 (-)
LP/J MGP_LPJ_G0023270
 protein coding gene Chr17:25139035-25144740 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023182
 protein coding gene Chr17:26416779-26422492 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023810
 protein coding gene Chr17:24544503-24550216 (-)
PWK/PhJ MGP_PWKPhJ_G0022339
 protein coding gene Chr17:22483312-22489056 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022157
 protein coding gene Chr17:22615681-22621412 (-)
WSB/EiJ MGP_WSBEiJ_G0022653
 protein coding gene Chr17:24597418-24603113 (-)



Homology
more
  • Human Ortholog
    MSLN, mesothelin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MSLN, mesothelin
  • Synonyms
    MPF, SMRP
  • Links
    NCBI Gene ID: 10232
    neXtProt AC: NX_Q13421
    UniProt: Q13421

  • Chr Location
    16p13.3; chr16:760734-768865 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human MSLN associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    20 phenotype references
Mice homozygous for disruptions in this allele display a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    840
  • Tissues
    27
  • cDNA Data
    20
  • Literature Summary
    8
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 56047 NCBI Gene Model | MGI Sequence Detail 5766 C57BL/6J ±  kb
transcript NM_018857 RefSeq | MGI Sequence Detail 2186 C57BL/6  
polypeptide Q61468 UniProt | EBI | MGI Sequence Detail 625 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    cDNA 20
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 52
    Developmental Gene Expression 8
    Gene Ontology 6
    Phenotypes 20
  • Earliest
    J:63219 Kojima T, et al., Molecular cloning and expression of megakaryocyte potentiating factor cDNA. J Biol Chem. 1995 Sep 15;270(37):21984-90
  • Latest
    J:345835 Qiu C, et al., A single-cell time-lapse of mouse prenatal development from gastrula to birth. Nature. 2024 Feb;626(8001):1084-1093
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory