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Ttyh1 Gene Detail
Summary
  • Symbol
    Ttyh1
  • Name
    tweety family member 1
  • Synonyms
    4930459B04Rik, 6330408P11Rik, tty
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889007
    NCBI Gene: 57776
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:4122418-4139206 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 2.38 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    543 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889007
 protein coding gene Chr7:4122407-4139707 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031537
 protein coding gene Chr7:1043082-1060370 (+)
A/J MGP_AJ_G0031511
 protein coding gene Chr7:1020796-1039031 (+)
AKR/J MGP_AKRJ_G0031439
 protein coding gene Chr7:1079065-1096405 (+)
BALB/cJ MGP_BALBcJ_G0031519
 protein coding gene Chr7:1092729-1112561 (+)
C3H/HeJ MGP_C3HHeJ_G0031240
 protein coding gene Chr7:1073155-1093212 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031980
 protein coding gene Chr7:1074646-1091942 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029104
 protein coding gene Chr7:818352-835963 (+)
CAST/EiJ MGP_CASTEiJ_G0030604
 protein coding gene Chr7:1016936-1035675 (+)
CBA/J MGP_CBAJ_G0031198
 protein coding gene Chr7:1269597-1286718 (+)
DBA/2J MGP_DBA2J_G0031357
 protein coding gene Chr7:1002669-1019953 (+)
FVB/NJ MGP_FVBNJ_G0031309
 protein coding gene Chr7:984413-1001626 (+)
LP/J MGP_LPJ_G0031442
 protein coding gene Chr7:1133395-1152648 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031348
 protein coding gene Chr7:1145401-1165014 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032010
 protein coding gene Chr7:1016544-1033846 (+)
PWK/PhJ MGP_PWKPhJ_G0030332
 protein coding gene Chr7:1204790-1222714 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030157
 protein coding gene Chr7:1145947-1163495 (+)
WSB/EiJ MGP_WSBEiJ_G0030699
 protein coding gene Chr7:1044273-1063013 (+)



Homology
more
  • Human Ortholog
    TTYH1, tweety family member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TTYH1, tweety family member 1
  • Links
    NCBI Gene ID: 57348
    neXtProt AC: NX_Q9H313
    UniProt: Q9H313

  • Chr Location
    19q13.42; chr19:54415219-54436904 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display embryonic lethality before implantation with arrest before the blastocyst stage and mitotic failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1065
  • Tissues
    132
  • cDNA Data
    79
  • Literature Summary
    17
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 57776 NCBI Gene Model | MGI Sequence Detail 16789 C57BL/6J ±  kb
transcript NM_021324 RefSeq | MGI Sequence Detail 3057 C57BL/6  
polypeptide Q9D3A9 UniProt | EBI | MGI Sequence Detail 450 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 85
    cDNA 81
    Primer pair 1
    Other 3

    Microarray probesets 9
Other
Accession IDs
less
MGI:1914663, MGI:1921927
References
more
  • Summaries
    All 57
    Developmental Gene Expression 17
    Gene Ontology 11
    Phenotypes 10
  • Earliest
    J:64127 Campbell HD, et al., Human and mouse homologues of the drosophila melanogaster tweety (tty) gene: A novel gene family encoding predicted transmembrane proteins. Genomics. 2000 Aug 15;68(1):89-92
  • Latest
    J:338811 Qu F, et al., Three-dimensional molecular architecture of mouse organogenesis. Nat Commun. 2023 Jul 31;14(1):4599
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory