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Fxyd1 Gene Detail
Summary
  • Symbol
    Fxyd1
  • Name
    FXYD domain-containing ion transport regulator 1
  • Synonyms
    0610012C17Rik, 1110006M24Rik, phospholemman, PLM, PML
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889273
    NCBI Gene: 56188
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30751103-30756624 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 19.29 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    195 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889273
 protein coding gene Chr7:30751103-30758332 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032058
 protein coding gene Chr7:30110455-30117335 (-)
A/J MGP_AJ_G0032035
 protein coding gene Chr7:29299965-29305402 (-)
AKR/J MGP_AKRJ_G0031968
 protein coding gene Chr7:30036623-30042059 (-)
BALB/cJ MGP_BALBcJ_G0032042
 protein coding gene Chr7:29475480-29480933 (-)
C3H/HeJ MGP_C3HHeJ_G0031759
 protein coding gene Chr7:30500002-30505505 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032508
 protein coding gene Chr7:31119775-31125278 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029558
 protein coding gene Chr7:30253979-30259484 (-)
CAST/EiJ MGP_CASTEiJ_G0031095
 protein coding gene Chr7:23747222-23752720 (-)
CBA/J MGP_CBAJ_G0031727
 protein coding gene Chr7:32579015-32584492 (-)
DBA/2J MGP_DBA2J_G0031879
 protein coding gene Chr7:29014889-29020306 (-)
FVB/NJ MGP_FVBNJ_G0031835
 protein coding gene Chr7:29133884-29139386 (-)
LP/J MGP_LPJ_G0031960
 protein coding gene Chr7:30450462-30455959 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031872
 protein coding gene Chr7:31803914-31809335 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032534
 protein coding gene Chr7:29549184-29554602 (-)
PWK/PhJ MGP_PWKPhJ_G0030817
 protein coding gene Chr7:24049322-24054869 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030654
 protein coding gene Chr7:20537854-20543352 (-)
WSB/EiJ MGP_WSBEiJ_G0031205
 protein coding gene Chr7:29955527-29961060 (-)



Homology
more
  • Human Ortholog
    FXYD1, FXYD domain containing ion transport regulator 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FXYD1, FXYD domain containing ion transport regulator 1
  • Synonyms
    PLM
  • Links
    NCBI Gene ID: 5348
    neXtProt AC: NX_O00168
    UniProt: O00168

  • Chr Location
    19q13.12; chr19:35137188-35143109 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Adult mice homozygous for a knock-out allele exhibit cardiac hypertrophy, increased ejection fraction, and a 50% reduction in total Na-K-ATPase activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    745
  • Tissues
    21
  • cDNA Data
    67
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036570 Ensembl Gene Model | MGI Sequence Detail 5522 C57BL/6J ±  kb
    transcript ENSMUST00000206474 Ensembl | MGI Sequence Detail 572 Not Applicable  
    polypeptide ENSMUSP00000145920 Ensembl | MGI Sequence Detail 92 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      cDNA 68
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1915607, MGI:1915796
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 8
      Gene Ontology 6
      Phenotypes 24
    • Earliest
      J:64123 Sweadner KJ, et al., The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. Genomics. 2000 Aug 15;68(1):41-56
    • Latest
      J:341308 Bubb KJ, et al., FXYD1 Is Protective Against Vascular Dysfunction. Hypertension. 2021 Jun;77(6):2104-2116
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory