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Gsdma Gene Detail
Summary
  • Symbol
    Gsdma
  • Name
    gasdermin A
  • Synonyms
    Gsdm, Gsdm1, Gsdma1, H312E
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889509
    NCBI Gene: 57911
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:98555177-98568534 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 62.34 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    593 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889509
 protein coding gene Chr11:98555163-98568534 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019067
 protein coding gene Chr11:101255996-101269270 (+)
A/J MGP_AJ_G0019035
 protein coding gene Chr11:97019891-97033665 (+)
AKR/J MGP_AKRJ_G0019005
 protein coding gene Chr11:100027986-100041974 (+)
BALB/cJ MGP_BALBcJ_G0019009
 protein coding gene Chr11:97512413-97528701 (+)
C3H/HeJ MGP_C3HHeJ_G0018822
 protein coding gene Chr11:100157576-100183703 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019460
 protein coding gene Chr11:104342255-104355533 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017092
 protein coding gene Chr11:94577025-94590089 (+)
CAST/EiJ MGP_CASTEiJ_G0018376
 protein coding gene Chr11:101146034-101165926 (+)
CBA/J MGP_CBAJ_G0018793
 protein coding gene Chr11:108694975-108720605 (+)
DBA/2J MGP_DBA2J_G0018901
 protein coding gene Chr11:96579650-96592910 (+)
FVB/NJ MGP_FVBNJ_G0018890
 protein coding gene Chr11:96079118-96100009 (+)
LP/J MGP_LPJ_G0018971
 protein coding gene Chr11:101716426-101730654 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018917
 protein coding gene Chr11:108418434-108435630 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019500
 protein coding gene Chr11:100367300-100383127 (+)
PWK/PhJ MGP_PWKPhJ_G0018147
 protein coding gene Chr11:97599902-97620248 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0018425
 protein coding gene Chr11:100320870-100334469 (+)



Homology
more
  • Human Ortholog
    GSDMA, gasdermin A
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GSDMA, gasdermin A
  • Synonyms
    FKSG9, GSDM, GSDM1
  • Links
    NCBI Gene ID: 284110
    neXtProt AC: NX_Q96QA5
    UniProt: Q96QA5

  • Chr Location
    17q21.1; chr17:39953263-39977768 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased susceptibility to bacterial infection with a lack of pyroptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    20
  • cDNA Data
    25
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000017204 Ensembl Gene Model | MGI Sequence Detail 13358 C57BL/6J ±  kb
transcript ENSMUST00000017348 Ensembl | MGI Sequence Detail 2726 Not Applicable  
polypeptide ENSMUSP00000017348 Ensembl | MGI Sequence Detail 446 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 28
    Genomic 1
    cDNA 26
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2144607
References
more
  • Summaries
    All 42
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 14
  • Earliest
    J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
  • Latest
    J:349394 Fattinger SA, et al., Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice. Proc Natl Acad Sci U S A. 2023 Nov 28;120(48):e2315503120
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory