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Map7mshi
Spontaneous Allele Detail
Summary
Symbol: Map7mshi
Name: microtubule-associated protein 7; male sterility and histoincompatibility
MGI ID: MGI:1889849
Gene: Map7  Location: Chr10:20024666-20157336 bp, + strand  Genetic Position: Chr10, 9.75 cM
Alliance: Map7mshi page
Map7mshi/Map7mshi mice display abnormal seminiferous epithelium morphology

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  BALB/cBy
Mutation
description
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
 
Mutation details: A large 13,080 bp deletion begins at nucleotide 1616 in intron 10 and extends to nucleotide 1959 in the 3' downstream sequence beyond exon 18. Exon 10 is then spliced to a cryptic "exon 11M" 4213 bp downstream of the deletion breakpoint. Exon 11M is, in turn, spliced to a second cryptic "exon 12M" located 830 bp downstream of exon 11M. The resulting 1724 nucleotide transcript is predicted to code for a 457 amino acid mutant protein. (J:148349)
Inheritance:    Recessive
Phenotypes
Key:
hm homozygous ht heterozygous tg involves transgenes √ phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Allelic Composition
Genetic Background
Cell Line(s)
hm1
Map7mshi/Map7mshi
B6.CBy-Map7mshi/Csu
 
hm2
Map7mshi/Map7mshi
involves: BALB/cBy
 
ht3
Map7Gt(ROSABetageo)1Sor/Map7mshi
involves: 129S4/SvJaeSor * BALB/cBy * C57BL/6J
 
Phenotypes:
Affected Systems
hm1
hm2
ht3
show or hide all annotated terms Sex:
   
cellular
√ √
decreased male germ cell number
√
arrest of male meiosis
√
endocrine/exocrine glands
√ √ √
abnormal seminiferous tubule morphology
√ √ √
abnormal seminiferous tubule epithelium morphology
√
ectopic Sertoli cells
√
small seminiferous tubules
√ √
increased Leydig cell number
√
small testis
√
decreased testis weight
√ √
immune system
√ √
decreased length of allograft survival
√ √
reproductive system
√ √ √
decreased male germ cell number
√
arrest of male meiosis
√
abnormal seminiferous tubule morphology
√ √ √
abnormal seminiferous tubule epithelium morphology
√
ectopic Sertoli cells
√
small seminiferous tubules
√ √
increased Leydig cell number
√
small testis
√
decreased testis weight
√ √
male infertility
√ √ √
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 8 assay results
2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Map7 Mutation:  240 strains or lines available
References
Original:  J:37165 Ward-Bailey PF, et al., A new mouse mutation causing male sterility and histoincompatibility. Mamm Genome. 1996 Nov;7(11):793-7
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory