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Gsdme Gene Detail
Summary
  • Symbol
    Gsdme
  • Name
    gasdermin E
  • Synonyms
    2310037D07Rik, 4932441K13Rik, Dfna5, Dfna5h, Fin15
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889850
    NCBI Gene: 54722
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:50167013-50240837 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 24.13 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2079 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889850
 protein coding gene Chr6:50165868-50240842 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030728
 protein coding gene Chr6:49284534-49360503 (-)
A/J MGP_AJ_G0030699
 protein coding gene Chr6:46988170-47066165 (-)
AKR/J MGP_AKRJ_G0030624
 protein coding gene Chr6:48647074-48724200 (-)
BALB/cJ MGP_BALBcJ_G0030709
 protein coding gene Chr6:47329885-47406393 (-)
C3H/HeJ MGP_C3HHeJ_G0030422
 protein coding gene Chr6:48663955-48745400 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031164
 protein coding gene Chr6:50397137-50477132 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028371
 protein coding gene Chr6:44595818-44676169 (-)
CAST/EiJ MGP_CASTEiJ_G0029826
 protein coding gene Chr6:48371774-48450494 (-)
CBA/J MGP_CBAJ_G0030397
 protein coding gene Chr6:52514913-52601884 (-)
DBA/2J MGP_DBA2J_G0030546
 protein coding gene Chr6:46898702-46974387 (-)
FVB/NJ MGP_FVBNJ_G0030498
 protein coding gene Chr6:46538842-46618345 (-)
LP/J MGP_LPJ_G0030631
 protein coding gene Chr6:49241480-49318675 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030532
 protein coding gene Chr6:55230327-55307319 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031193
 protein coding gene Chr6:48556836-48636330 (-)
PWK/PhJ MGP_PWKPhJ_G0029538
 protein coding gene Chr6:46467865-46547374 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029374
 protein coding gene Chr6:47882868-47960887 (-)
WSB/EiJ MGP_WSBEiJ_G0029903
 protein coding gene Chr6:48519678-48598206 (-)



Homology
more
  • Human Ortholog
    GSDME, gasdermin E
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GSDME, gasdermin E
  • Synonyms
    DFNA5, ICERE-1
  • Links
    NCBI Gene ID: 1687
    neXtProt AC: NX_O60443
    UniProt: O60443

  • Chr Location
    7p15.3; chr7:24698355-24795539 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human GSDME associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display abnormal numbers of cochlear hair cell but have normal hearing. Mice homozygous for another knock-out allele exhibit normal hearing but protection from chemotherapy drug-induced tissue damage and weight loss.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    779
  • Tissues
    57
  • cDNA Data
    9
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54722 NCBI Gene Model | MGI Sequence Detail 73825 C57BL/6J ±  kb
    transcript NM_018769 RefSeq | MGI Sequence Detail 2135 C57BL/6  
    polypeptide Q9Z2D3 UniProt | EBI | MGI Sequence Detail 512 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 2
      cDNA 11
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-33747, MGI:106063, MGI:1921667, MGI:1923695, MGI:3703053, MGI:5908157
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 34
    • Earliest
      J:32076 Guthridge MA, et al., Induction of expression of growth-related genes by FGF-4 in mouse fibroblasts. Oncogene. 1996 Mar 21;12(6):1267-78
    • Latest
      J:351181 Ma F, et al., Gasdermin E dictates inflammatory responses by controlling the mode of neutrophil death. Nat Commun. 2024 Jan 9;15(1):386
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory