early conceptus |
embryo ectoderm |
embryo endoderm |
embryo mesoderm |
embryo mesenchyme |
extraembryonic component |
alimentary system |
auditory system |
branchial arches |
cardiovascular system |
connective tissue |
endocrine system |
exocrine system |
hemolymphoid system |
integumental system |
limbs |
liver and biliary system |
musculoskeletal system |
nervous system |
olfactory system |
reproductive system |
respiratory system |
urinary system |
visual system |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Transcription Start Site | Location | Distance from Gene 5'-end |
| Tssr29089 | Chr3:52175795-52175809 (+) | 44 bp |
| Tssr29090 | Chr3:52175814-52175826 (+) | 62 bp |
| Tssr29091 | Chr3:52175828-52175845 (+) | 79 bp |
| Tssr29092 | Chr3:52177619-52177629 (+) | 1,866 bp |
| Tssr29093 | Chr3:52183574-52183580 (+) | 7,819 bp |
| QTL | Genetic Location* | Genome Location (GRCm39) | Reference | QTL Note |
| Gdfsc1 | Chr3, syntenic | J:313290 | QTL Gdfsc1 (GDF11 serum concentration 1) maps to Chr 3: 3.039589 - 9.983782 Mb in close proximity to the gene Hey1, a transcriptional repressor. Bioinformatic analyses located putative binding sites for the HEY1 protein upstream of the Gdf11 gene in the mouse and human genomes. While these findings indirectly support Hey1 as a candidate gene behind circulating GDF11 levels, the authors also cannot exclude other plausible genes within the same locus, such as Stathmin-2 (Stmn2). Stmn2 is another reasonable candidate as it is expressed in both murine and human heart tissue throughout development and into adulthood (Asp et al. 2019; Bult et al. 2019; Smith et al. 2019). QTL Smc1 (serum myostatin concentration 1) maps to Chr 3: 52.26269 - 52.71985 Mb. The peak is located in close proximity to protein-coding gene Forkhead Box O1 (Foxo1; MGI:1890077). | |
| Smc1 | Chr3, syntenic | J:313290 | QTL Gdfsc1 (GDF11 serum concentration 1) maps to Chr 3: 3.039589 - 9.983782 Mb in close proximity to the gene Hey1, a transcriptional repressor. Bioinformatic analyses located putative binding sites for the HEY1 protein upstream of the Gdf11 gene in the mouse and human genomes. While these findings indirectly support Hey1 as a candidate gene behind circulating GDF11 levels, the authors also cannot exclude other plausible genes within the same locus, such as Stathmin-2 (Stmn2). Stmn2 is another reasonable candidate as it is expressed in both murine and human heart tissue throughout development and into adulthood (Asp et al. 2019; Bult et al. 2019; Smith et al. 2019). QTL Smc1 (serum myostatin concentration 1) maps to Chr 3: 52.26269 - 52.71985 Mb. The peak is located in close proximity to protein-coding gene Forkhead Box O1 (Foxo1; MGI:1890077). |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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