Lhx2<tm1Dra> Targeted Allele Detail MGI Mouse (MGI:1890208)

Lhx2^tm1Dra
Targeted Allele Detail

Summary

Symbol:	Lhx2^tm1Dra
Name:	LIM homeobox protein 2; targeted mutation 1, John Drago
MGI ID:	MGI:1890208
Synonyms:	Lh2^sKO, Lhx -
Gene:	Lhx2 Location: Chr2:38229293-38259745 bp, + strand Genetic Position: Chr2, 24.31 cM, cytoband B
Alliance:	Lhx2^tm1Dra page

Hair follicles of tamoxifen-treated Lhx2^tm1.1Lcar/Lhx2^tm1Dra Tg(CAG-cre/Esr1*)5Amc/0 mice arrest during anagen progression and are unable to assemble a normal hair shaft

Show the 1 phenotype image(s) involving this allele.

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:64676
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Mutation
description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A neomycin resistance cassette replaced exons 2 and 3, which encode the LIM domains, the domain linking these two, and the homeodomains of the protein. (J:64676)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	341 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	16 anatomical structure(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Lhx2 Mutation:	12 strains or lines available

References

Original:	J:64676 Porter FD, et al., Lhx2, a LIM homeobox gene, is required for eye, forebrain, and definitive erythrocyte development. Development. 1997 Aug;124(15):2935-44
All:	40 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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