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Plvap Gene Detail
Summary
  • Symbol
    Plvap
  • Name
    plasmalemma vesicle associated protein
  • Synonyms
    MECA32, PV-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1890497
    NCBI Gene: 84094
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:71950409-71964396 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.43 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    331 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1890497
 protein coding gene Chr8:71950397-71964446 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033750
 protein coding gene Chr8:71896726-71915897 (-)
A/J MGP_AJ_G0033733
 protein coding gene Chr8:68968863-68982545 (-)
AKR/J MGP_AKRJ_G0033658
 protein coding gene Chr8:71003469-71020984 (-)
BALB/cJ MGP_BALBcJ_G0033729
 protein coding gene Chr8:69139677-69154732 (-)
C3H/HeJ MGP_C3HHeJ_G0033439
 protein coding gene Chr8:71580667-71595860 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034247
 protein coding gene Chr8:74636614-74649589 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031189
 protein coding gene Chr8:63609094-63622861 (-)
CAST/EiJ MGP_CASTEiJ_G0032764
 protein coding gene Chr8:71046097-71061116 (-)
CBA/J MGP_CBAJ_G0033417
 protein coding gene Chr8:77279636-77296278 (-)
DBA/2J MGP_DBA2J_G0033571
 protein coding gene Chr8:68700567-68714470 (-)
FVB/NJ MGP_FVBNJ_G0033513
 protein coding gene Chr8:67779704-67795782 (-)
LP/J MGP_LPJ_G0033658
 protein coding gene Chr8:71873166-71888396 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033560
 protein coding gene Chr8:79833944-79848225 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034264
 protein coding gene Chr8:71065954-71080578 (-)
PWK/PhJ MGP_PWKPhJ_G0032471
 protein coding gene Chr8:67975862-67989835 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032308
 protein coding gene Chr8:70013588-70027118 (-)
WSB/EiJ MGP_WSBEiJ_G0032879
 protein coding gene Chr8:71414560-71430999 (-)



Homology
more
  • Human Ortholog
    PLVAP, plasmalemma vesicle associated protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLVAP, plasmalemma vesicle associated protein
  • Synonyms
    DIAR10, FELS, gp68, PV-1, PV1
  • Links
    NCBI Gene ID: 83483
    neXtProt AC: NX_Q9BX97
    UniProt: Q9BX97

  • Chr Location
    19p13.11; chr19:17351450-17377342 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PLVAP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    51 phenotypes from 3 alleles in 9 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display background sensitive lethality, absence of diaphragms from fenestrated endothelia, increased vascular permeability, hypoproteinemia, ascites, edema, xanthoma and increased plasma triglyceride levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    822
  • Tissues
    65
  • cDNA Data
    49
  • Literature Summary
    54
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034845 Ensembl Gene Model | MGI Sequence Detail 13988 C57BL/6J ±  kb
    transcript ENSMUST00000048452 Ensembl | MGI Sequence Detail 1987 Not Applicable  
    polypeptide ENSMUSP00000035404 Ensembl | MGI Sequence Detail 438 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 54
      cDNA 49
      Primer pair 4
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 54
      Gene Ontology 6
      Phenotypes 26
    • Earliest
      J:24500 Hallmann R, et al., Novel mouse endothelial cell surface marker is suppressed during differentiation of the blood brain barrier. Dev Dyn. 1995 Apr;202(4):325-32
    • Latest
      J:343285 Lettieri A, et al., SEMA6A drives GnRH neuron-dependent puberty onset by tuning median eminence vascular permeability. Nat Commun. 2023 Dec 7;14(1):8097
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory