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F12 Gene Detail
Summary
  • Symbol
    F12
  • Name
    coagulation factor XII (Hageman factor)
  • Synonyms
    FXII
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891012
    NCBI Gene: 58992
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:55565771-55574606 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 30.06 cM, cytoband B2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    317 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891012
 protein coding gene Chr13:55565771-55574617 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020596
 protein coding gene Chr13:54898251-54911333 (-)
A/J MGP_AJ_G0020550
 protein coding gene Chr13:52867469-52878569 (-)
AKR/J MGP_AKRJ_G0020528
 protein coding gene Chr13:54426413-54446043 (-)
BALB/cJ MGP_BALBcJ_G0020546
 protein coding gene Chr13:53096087-53109887 (-)
C3H/HeJ MGP_C3HHeJ_G0020345
 protein coding gene Chr13:54239288-54253175 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020980
 protein coding gene Chr13:56552509-56567935 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018562
 protein coding gene Chr13:50815572-50824394 (-)
CAST/EiJ MGP_CASTEiJ_G0019859
 protein coding gene Chr13:54341259-54353983 (-)
CBA/J MGP_CBAJ_G0020305
 protein coding gene Chr13:58721778-58734115 (-)
DBA/2J MGP_DBA2J_G0020428
 protein coding gene Chr13:52420443-52432908 (-)
FVB/NJ MGP_FVBNJ_G0020407
 protein coding gene Chr13:51890510-51899002 (-)
LP/J MGP_LPJ_G0020504
 protein coding gene Chr13:55155349-55166848 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020436
 protein coding gene Chr13:58199650-58208203 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021023
 protein coding gene Chr13:54014244-54024573 (-)
PWK/PhJ MGP_PWKPhJ_G0019615
 protein coding gene Chr13:52446594-52455562 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019442
 protein coding gene Chr13:52939583-52948130 (-)
WSB/EiJ MGP_WSBEiJ_G0019921
 protein coding gene Chr13:54371695-54379606 (-)



Homology
more
  • Human Ortholog
    F12, coagulation factor XII
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    F12, coagulation factor XII
  • Synonyms
    HAE3, HAEX, HAF
  • Links
    NCBI Gene ID: 2161
    neXtProt AC: NX_P00748
    UniProt: P00748

  • Chr Location
    5q35.3; chr5:177402133-177416583 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with F12 mouse models; 7 with human F12 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are protected from ischemic brain injury in an experimental stroke model, without exhibiting an increase in infarct-associated hemorrhage. Another null mouse shows decreased plasma bradykinin levels and prolonged activated partial thromboplastin times.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    770
  • Tissues
    14
  • cDNA Data
    49
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021492 Ensembl Gene Model | MGI Sequence Detail 8836 C57BL/6J ±  kb
transcript ENSMUST00000021948 Ensembl | MGI Sequence Detail 1960 Not Applicable  
polypeptide ENSMUSP00000021948 Ensembl | MGI Sequence Detail 597 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 51
    cDNA 49
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 62
    Developmental Gene Expression 3
    Diseases 2
    Gene Ontology 8
    Phenotypes 30
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:354028 Ballard-Kordeliski A, et al., 4D intravital imaging studies identify platelets as the predominant cellular procoagulant surface in a mouse hemostasis model. Blood. 2024 Sep 5;144(10):1116-1126
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory