Myl10 MGI Mouse Gene Detail - MGI:1891705 - myosin, light chain 10, regulatory

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Myl10 Gene Detail

Symbol

Myl10
Name

myosin, light chain 10, regulatory
Synonyms

1700027I08Rik, Mylc2pl, PLRLC, PLRLC-A, PLRLC-B, PLRLC-C

Feature Type

protein coding gene
IDs

MGI:1891705
NCBI Gene: 59310
Alliance

gene page
Transcription Start Sites

20 TSS

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Sequence Map

Chr5:136722000-136729948 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 76.03 cM, cytoband G1
Mapping Data

2 experiments

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SNPs within 2kb

433 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1891705	protein coding gene	Chr5:136717749-136730711 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030207	protein coding gene	Chr5:141366073-141375985 (+)
A/J	MGP_AJ_G0030175	protein coding gene	Chr5:135262866-135270494 (+)
AKR/J	MGP_AKRJ_G0030108	protein coding gene	Chr5:139630158-139643200 (+)
BALB/cJ	MGP_BALBcJ_G0030185	protein coding gene	Chr5:136617818-136625909 (+)
C3H/HeJ	MGP_C3HHeJ_G0029901	protein coding gene	Chr5:140249470-140257128 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032461	protein coding gene	Chr7:30236858-30240173 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027858	protein coding gene	Chr5:129542884-129549176 (+)
CAST/EiJ	MGP_CASTEiJ_G0029311	protein coding gene	Chr5:139653283-139663281 (+)
CBA/J	MGP_CBAJ_G0029871	protein coding gene	Chr5:152312638-152323741 (+)
DBA/2J	MGP_DBA2J_G0030022	protein coding gene	Chr5:135158807-135166466 (+)
FVB/NJ	MGP_FVBNJ_G0029977	protein coding gene	Chr5:134331280-134338919 (+)
LP/J	MGP_LPJ_G0030111	protein coding gene	Chr5:141791026-141800432 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030009	protein coding gene	Chr5:155270606-155278258 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030678	protein coding gene	Chr5:139456885-139464884 (+)
PWK/PhJ	MGP_PWKPhJ_G0029024	protein coding gene	Chr5:134237896-134246281 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028860	protein coding gene	Chr5:137035935-137043674 (+)
WSB/EiJ	MGP_WSBEiJ_G0029384	protein coding gene	Chr5:140187669-140197498 (+)

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Human Ortholog

MYL10, myosin light chain 10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MYL10, myosin light chain 10
Synonyms

MYLC2PL, PLRLC
Links

HGNC:29825

NCBI Gene ID: 93408

neXtProt AC: NX_Q9BUA6

UniProt: Q9BUA6
Chr Location

7q22.1; chr7:101613330-101629296 (-) GRCh38

MGI Vertebrate Homology

Myl10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MYL10
Gene Tree

Myl10

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Phenotype Summary

3 phenotype references

All Mutations and Alleles

2
Endonuclease-mediated

1
Targeted

1
Find Mice (IMSR)

39 strains or lines available

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All GO Annotations

7
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

4

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase myl10

ZFIN myl10

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All Sequences

52
RefSeq

12
UniProt

4
CCDS

CCDS51668.1, CCDS80433.1, CCDS80434.1

Ensembl

ENSMUSG00000005474 (Evidence)
NCBI Gene

59310

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000005474	Ensembl Gene Model \| MGI Sequence Detail	7949	C57BL/6J	± kb
	transcript	ENSMUST00000005611	Ensembl \| MGI Sequence Detail	688	Not Applicable
	polypeptide	ENSMUSP00000005611	Ensembl \| MGI Sequence Detail	147	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000010843 myosin regulatory light chain 10

(term hierarchy)
InterPro Domains

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR050403 Myosin Regulatory Light Chain

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All nucleic 5

cDNA 5

Microarray probesets 3

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MGI:1917247

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Summaries

All 25

Gene Ontology 5

Phenotypes 3
Earliest

J:1334 Oltz EM, et al., A novel regulatory myosin light chain gene distinguishes pre-B cell subsets and is IL-7 inducible. EMBO J. 1992 Jul;11(7):2759-67
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Myl10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr49256	Chr5:136720374-136720383 (+)	-1,621 bp
Tssr49257	Chr5:136721674-136721691 (+)	-317 bp
Tssr49258	Chr5:136721810-136721824 (+)	-183 bp
Tssr49259	Chr5:136721873-136721884 (+)	-121 bp
Tssr49260	Chr5:136721938-136721958 (+)	-52 bp
Tssr49261	Chr5:136722450-136722466 (+)	458 bp
Tssr49262	Chr5:136722468-136722496 (+)	482 bp
Tssr49263	Chr5:136722511-136722516 (+)	514 bp
Tssr49264	Chr5:136722521-136722537 (+)	529 bp
Tssr49265	Chr5:136722975-136722988 (+)	982 bp
Tssr49266	Chr5:136722997-136723003 (+)	1,000 bp
Tssr49267	Chr5:136723067-136723109 (+)	1,088 bp
Tssr49268	Chr5:136724045-136724057 (+)	2,051 bp
Tssr49269	Chr5:136724058-136724067 (+)	2,063 bp
Tssr49270	Chr5:136724069-136724085 (+)	2,077 bp
Tssr49271	Chr5:136724094-136724100 (+)	2,097 bp
Tssr49272	Chr5:136726659-136726664 (+)	4,662 bp
Tssr49273	Chr5:136726673-136726682 (+)	4,678 bp
Tssr49274	Chr5:136726683-136726736 (+)	4,710 bp
Tssr49275	Chr5:136729857-136729863 (+)	7,860 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24