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Wbp11 Gene Detail
Summary
  • Symbol
    Wbp11
  • Name
    WW domain binding protein 11
  • Synonyms
    2510026P17Rik, D6Wsu113e, Npwbp, SIPP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891823
    NCBI Gene: 60321
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:136790652-136805214 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 66.72 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    627 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891823
 protein coding gene Chr6:136790652-136805231 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031426
 protein coding gene Chr6:141274107-141290385 (-)
A/J MGP_AJ_G0031402
 protein coding gene Chr6:135665788-135680161 (-)
AKR/J MGP_AKRJ_G0031329
 protein coding gene Chr6:139800753-139820606 (-)
BALB/cJ MGP_BALBcJ_G0031409
 protein coding gene Chr6:135543703-135563007 (-)
C3H/HeJ MGP_C3HHeJ_G0031130
 protein coding gene Chr6:139829023-139857650 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031870
 protein coding gene Chr6:145151704-145169920 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029000
 protein coding gene Chr6:134822774-134835986 (-)
CAST/EiJ MGP_CASTEiJ_G0030499
 protein coding gene Chr6:139354943-139368769 (-)
CBA/J MGP_CBAJ_G0031090
 protein coding gene Chr6:150545409-150560560 (-)
DBA/2J MGP_DBA2J_G0031247
 protein coding gene Chr6:134558924-134573073 (-)
FVB/NJ MGP_FVBNJ_G0031198
 protein coding gene Chr6:133453220-133475844 (-)
LP/J MGP_LPJ_G0031331
 protein coding gene Chr6:141391974-141412174 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031238
 protein coding gene Chr6:154435807-154452885 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031902
 protein coding gene Chr6:139563595-139577655 (-)
PWK/PhJ MGP_PWKPhJ_G0030225
 protein coding gene Chr6:133068861-133082705 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030049
 protein coding gene Chr6:137835754-137849188 (-)
WSB/EiJ MGP_WSBEiJ_G0030591
 protein coding gene Chr6:140191774-140219930 (-)



Homology
more
  • Human Ortholog
    WBP11, WW domain binding protein 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WBP11, WW domain binding protein 11
  • Synonyms
    BUG13, CFAP90, FAP90, NPWBP, PPP1R165, SIPP1, VCTERL, VCTRL, WBP-11
  • Links
    NCBI Gene ID: 51729
    neXtProt AC: NX_Q9Y2W2
    UniProt: Q9Y2W2

  • Chr Location
    12p12.3; chr12:14784582-14803486 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die prior to E8.5. Heterozygotes exhibit partial embryonic and postnatal lethality, and have defects in the axial skeleton, kidneys, and esophagus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    727
  • Tissues
    14
  • cDNA Data
    146
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 60321 NCBI Gene Model | MGI Sequence Detail 14563 C57BL/6J ±  kb
    transcript NM_021714 RefSeq | MGI Sequence Detail 2722 ZRU/MplStud  
    polypeptide Q923D5 UniProt | EBI | MGI Sequence Detail 641 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 149
      Genomic 1
      cDNA 146
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-34158, MGI:106464, MGI:1919707
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 2
      Gene Ontology 3
      Phenotypes 8
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:300837 Martin EMMA, et al., Heterozygous loss of WBP11 function causes multiple congenital defects in humans and mice. Hum Mol Genet. 2021 Jan 21;29(22):3662-3678
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory