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Sfn Gene Detail
Summary
  • Symbol
    Sfn
  • Name
    stratifin
  • Synonyms
    14-3-3, 14-3-3 sigma, Er, MME1, Ywhas
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891831
    NCBI Gene: 55948
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:133327867-133329163 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 66.25 cM, cytoband D3
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    112 from dbSNP Build 142
  • Strain Annotations
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891831
 protein coding gene Chr4:133327867-133329479 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028901
 protein coding gene Chr4:135882427-135885408 (-)
A/J MGP_AJ_G0028860
 protein coding gene Chr4:130183263-130184696 (-)
AKR/J MGP_AKRJ_G0033659
 protein coding gene Chr8:71033563-71035250 (+)
BALB/cJ MGP_BALBcJ_G0028883
 protein coding gene Chr4:130815498-130818552 (-)
C3H/HeJ MGP_C3HHeJ_G0028597
 protein coding gene Chr4:134139469-134141004 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029325
 protein coding gene Chr4:140743288-140747393 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026596
 protein coding gene Chr4:123248224-123249464 (-)
CAST/EiJ MGP_CASTEiJ_G0028030
 protein coding gene Chr4:132250886-132253873 (-)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0028679
 protein coding gene Chr4:129492148-129493560 (-)
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0029363
 protein coding gene Chr4:134304615-134307505 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0032880
 protein coding gene Chr8:71442523-71443345 (+)



Homology
more
  • Human Ortholog
    SFN, stratifin
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SFN, stratifin
  • Synonyms
    YWHAS
  • Links
    NCBI Gene ID: 2810
    neXtProt AC: NX_P31947
    UniProt: P31947

  • Chr Location
    1p36.11; chr1:26863149-26864456 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human SFN associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    94 phenotypes from 3 alleles in 6 genetic backgrounds
    18 phenotypes from multigenic genotypes
    12 images
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice show impaired B-cell homeostasis, BCR signaling, and T cell-independent B-cell responses. Homozygous hypomorphs show altered mammary epithelial morphology. Spontaneous mutants die at birth from respiratory stress with severe anomalies inskin, limbs, tails, face and oral cavity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    879
  • Tissues
    145
  • cDNA Data
    104
  • Literature Summary
    36
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 55948 NCBI Gene Model | MGI Sequence Detail 1297 C57BL/6J ±  kb
    transcript NM_018754 RefSeq | MGI Sequence Detail 1297 ZRU/MplStud  
    polypeptide O70456 UniProt | EBI | MGI Sequence Detail 248 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 115
      Genomic 1
      cDNA 104
      Primer pair 6
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-9568, MGI:95409
    References
    more
    • Summaries
      All 111
      Developmental Gene Expression 36
      Gene Ontology 13
      Phenotypes 40
    • Earliest
      J:6200 Guenet JL, et al., Repeated epilation: a genetic epidermal syndrome in mice. J Hered. 1979 Mar-Apr;70(2):90-4
    • Latest
      J:355487 Han Z, et al., The subcortical maternal complex modulates the cell cycle during early mammalian embryogenesis via 14-3-3. Nat Commun. 2024 Oct 15;15(1):8887
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory