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Sh3rf1 Gene Detail
Summary
  • Symbol
    Sh3rf1
  • Name
    SH3 domain containing ring finger 1
  • Synonyms
    2200003J05Rik, Posh, Sh3md2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913066
    NCBI Gene: 59009
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:61676906-61849105 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 30.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4919 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913066
 protein coding gene Chr8:61676906-61918327 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033634
 protein coding gene Chr8:61132768-61315412 (+)
A/J MGP_AJ_G0033616
 protein coding gene Chr8:58521102-58692196 (+)
AKR/J MGP_AKRJ_G0033541
 protein coding gene Chr8:60205000-60389895 (+)
BALB/cJ MGP_BALBcJ_G0033612
 protein coding gene Chr8:58775773-58951502 (+)
C3H/HeJ MGP_C3HHeJ_G0033322
 protein coding gene Chr8:60874142-61057302 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034129
 protein coding gene Chr8:63460387-63653782 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031077
 protein coding gene Chr8:53770273-53938253 (+)
CAST/EiJ MGP_CASTEiJ_G0032647
 protein coding gene Chr8:60288991-60461283 (+)
CBA/J MGP_CBAJ_G0033300
 protein coding gene Chr8:65750040-65952736 (+)
DBA/2J MGP_DBA2J_G0033454
 protein coding gene Chr8:58274728-58448598 (+)
FVB/NJ MGP_FVBNJ_G0033395
 protein coding gene Chr8:57582965-57753974 (+)
LP/J MGP_LPJ_G0033542
 protein coding gene Chr8:61097365-61276987 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033439
 protein coding gene Chr8:67864536-68052297 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034147
 protein coding gene Chr8:60461417-60642972 (+)
PWK/PhJ MGP_PWKPhJ_G0032356
 protein coding gene Chr8:57583183-57754263 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032192
 protein coding gene Chr8:59440577-59610299 (+)
WSB/EiJ MGP_WSBEiJ_G0032764
 protein coding gene Chr8:60785602-60969893 (+)



Homology
more
  • Human Ortholog
    SH3RF1, SH3 domain containing ring finger 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SH3RF1, SH3 domain containing ring finger 1
  • Synonyms
    POSH, RNF142, SH3MD2
  • Links
    NCBI Gene ID: 57630
    neXtProt AC: NX_Q7Z6J0
    UniProt: Q7Z6J0

  • Chr Location
    4q32.3-q33; chr4:169094259-169270956 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased dendritic spine length and density, impaired spatial learning and reference memory, impaired contextual conditioning, increased digging, impaired nest building, decreased social investigation, reduced vocalization, decreased excitatory postsynaptic current amplitude, and reduced long term potentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    792
  • Tissues
    53
  • cDNA Data
    61
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031642 Ensembl Gene Model | MGI Sequence Detail 172200 C57BL/6J ±  kb
    transcript ENSMUST00000034060 Ensembl | MGI Sequence Detail 5479 Not Applicable  
    polypeptide ENSMUSP00000034060 Ensembl | MGI Sequence Detail 891 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 62
      cDNA 62

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1916398, MGI:2142899
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 10
    • Earliest
      J:64936 Tapon N, et al., A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways. EMBO J. 1998 Mar 2;17(5):1395-404
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory