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Apoa5 Gene Detail
Summary
  • Symbol
    Apoa5
  • Name
    apolipoprotein A-V
  • Synonyms
    1300007O05Rik, Apoav, RAP3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913363
    NCBI Gene: 66113
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:46179931-46183217 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 25.37 cM, cytoband B
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    169 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913363
 protein coding gene Chr9:46179906-46183219 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034751
 protein coding gene Chr9:44900982-44904268 (+)
A/J MGP_AJ_G0034732
 protein coding gene Chr9:43615005-43618529 (+)
AKR/J MGP_AKRJ_G0034659
 protein coding gene Chr9:44504566-44507852 (+)
BALB/cJ MGP_BALBcJ_G0034723
 protein coding gene Chr9:43336170-43339456 (+)
C3H/HeJ MGP_C3HHeJ_G0034434
 protein coding gene Chr9:44978300-44981586 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035244
 protein coding gene Chr9:46180412-46183698 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032158
 protein coding gene Chr9:43144911-43148154 (+)
CAST/EiJ MGP_CASTEiJ_G0033756
 protein coding gene Chr9:44841745-44845029 (+)
CBA/J MGP_CBAJ_G0034406
 protein coding gene Chr9:47871239-47874525 (+)
DBA/2J MGP_DBA2J_G0034565
 protein coding gene Chr9:43485763-43489049 (+)
FVB/NJ MGP_FVBNJ_G0034506
 protein coding gene Chr9:42750613-42753899 (+)
LP/J MGP_LPJ_G0034646
 protein coding gene Chr9:45217116-45222180 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034550
 protein coding gene Chr9:49614624-49617910 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035265
 protein coding gene Chr9:44421702-44424988 (+)
PWK/PhJ MGP_PWKPhJ_G0033461
 protein coding gene Chr9:43407419-43410707 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033297
 protein coding gene Chr9:44753488-44756770 (+)
WSB/EiJ MGP_WSBEiJ_G0033869
 protein coding gene Chr9:44470959-44474245 (+)



Homology
more
  • Human Ortholog
    APOA5, apolipoprotein A5
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APOA5, apolipoprotein A5
  • Synonyms
    APOAV, RAP3
  • Links
    NCBI Gene ID: 116519
    neXtProt AC: NX_Q6Q788
    UniProt: Q6Q788

  • Chr Location
    11q23.3; chr11:116789367-116792420 (-)  GRCh38
Human Diseases
more
  • Diseases
    6 with human APOA5 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in increased triglyceride and VLDL cholesterol levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    63
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    185
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032079 Ensembl Gene Model | MGI Sequence Detail 3287 C57BL/6J ±  kb
    transcript ENSMUST00000034584 Ensembl | MGI Sequence Detail 2312 Not Applicable  
    polypeptide ENSMUSP00000034584 Ensembl | MGI Sequence Detail 368 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 185
      cDNA 185

      Microarray probesets 5
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 18
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:348105 Chen H, et al., Pre-eclamptic foetal programming predisposes offspring to hepatic steatosis via DNA methylation. Biochim Biophys Acta Mol Basis Dis. 2024 Apr 20;1870(5):167189
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory