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Serpinb1a Gene Detail
Summary
  • Symbol
    Serpinb1a
  • Name
    serine (or cysteine) peptidase inhibitor, clade B, member 1a
  • Synonyms
    1190005M04Rik, EIA, ELANH2, LEI, M/NEI, MNEI, ovalbumin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913472
    NCBI Gene: 66222
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:33026075-33035168 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 13.75 cM, cytoband A4
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    332 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913472
 protein coding gene Chr13:33026075-33037189 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020428
 protein coding gene Chr13:30845956-30857234 (-)
A/J MGP_AJ_G0020383
 protein coding gene Chr13:30006260-30016147 (-)
AKR/J MGP_AKRJ_G0020360
 protein coding gene Chr13:30666644-30680175 (-)
BALB/cJ MGP_BALBcJ_G0020378
 protein coding gene Chr13:30090725-30100622 (-)
C3H/HeJ MGP_C3HHeJ_G0020181
 protein coding gene Chr13:30654967-30663965 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020814
 protein coding gene Chr13:31881151-31890224 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018405
 protein coding gene Chr13:28326228-28335657 (-)
CAST/EiJ MGP_CASTEiJ_G0019698
 protein coding gene Chr13:30366522-30377011 (-)
CBA/J MGP_CBAJ_G0020137
 protein coding gene Chr13:33254005-33263095 (-)
DBA/2J MGP_DBA2J_G0020259
 protein coding gene Chr13:29510219-29519506 (-)
FVB/NJ MGP_FVBNJ_G0020244
 protein coding gene Chr13:29122015-29131456 (-)
LP/J MGP_LPJ_G0020336
 protein coding gene Chr13:31050689-31059695 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020270
 protein coding gene Chr13:33339042-33349160 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020855
 protein coding gene Chr13:30311006-30320075 (-)
PWK/PhJ MGP_PWKPhJ_G0019453
 protein coding gene Chr13:29699815-29709013 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019274
 protein coding gene Chr13:29240110-29260193 (-)
WSB/EiJ MGP_WSBEiJ_G0019760
 protein coding gene Chr13:30632799-30642832 (-)



Homology
more
  • Human Ortholog
    SERPINB1, serpin family B member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERPINB1, serpin family B member 1
  • Synonyms
    EI, ELANH2, HEL57, HEL-S-27, LEI, M/NEI, MNEI, PI-2, PI2
  • Links
    NCBI Gene ID: 1992
    neXtProt AC: NX_P30740
    UniProt: P30740

  • Chr Location
    6p25.2; chr6:2832332-2841959 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 2 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice fail to clear P. aeruginosa lung infection and show increased mortality associated with late-onset failed bacterial clearance, partly due to elevated neutrophil necrosis, release of neutrophil protease activity, higher cytokine production and proteolysis of surfactant protein-D.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    805
  • Tissues
    14
  • cDNA Data
    82
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000044734 Ensembl Gene Model | MGI Sequence Detail 9094 C57BL/6J ±  kb
    transcript ENSMUST00000076352 Ensembl | MGI Sequence Detail 1918 Not Applicable  
    polypeptide ENSMUSP00000075690 Ensembl | MGI Sequence Detail 379 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 87
      Genomic 3
      cDNA 83
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2145215
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 4
      Gene Ontology 11
      Phenotypes 27
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:306023 Dani N, et al., A cellular and spatial map of the choroid plexus across brain ventricles and ages. Cell. 2021 May 27;184(11):3056-3074.e21
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory