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Senp7 Gene Detail
Summary
  • Symbol
    Senp7
  • Name
    SUMO1/sentrin specific peptidase 7
  • Synonyms
    2410152H17Rik, 2810413I22Rik, 2900036C23Rik, 6030449K19Rik, mKIAA1707
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913565
    NCBI Gene: 66315
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:55869306-56010394 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 33.82 cM, cytoband C1.1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3973 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913565
 protein coding gene Chr16:55868701-56010394 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022887
 protein coding gene Chr16:55180820-55299350 (+)
A/J MGP_AJ_G0022854
 protein coding gene Chr16:52807600-52924000 (+)
AKR/J MGP_AKRJ_G0022826
 protein coding gene Chr16:54475815-54593621 (+)
BALB/cJ MGP_BALBcJ_G0022854
 protein coding gene Chr16:52911844-53025511 (+)
C3H/HeJ MGP_C3HHeJ_G0022617
 protein coding gene Chr16:54640000-54784800 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023302
 protein coding gene Chr16:56728207-56860560 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020813
 protein coding gene Chr16:52514743-52629685 (+)
CAST/EiJ MGP_CASTEiJ_G0022144
 protein coding gene Chr16:55054742-55175577 (+)
CBA/J MGP_CBAJ_G0022590
 protein coding gene Chr16:58962236-59131456 (+)
DBA/2J MGP_DBA2J_G0022722
 protein coding gene Chr16:52536701-52689306 (+)
FVB/NJ MGP_FVBNJ_G0022697
 protein coding gene Chr16:52329842-52447739 (+)
LP/J MGP_LPJ_G0022789
 protein coding gene Chr16:54981836-55105996 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022715
 protein coding gene Chr16:59315067-59449307 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023317
 protein coding gene Chr16:54608998-54763527 (+)
PWK/PhJ MGP_PWKPhJ_G0021883
 protein coding gene Chr16:52894260-53010175 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021713
 protein coding gene Chr16:54421307-54543273 (+)
WSB/EiJ MGP_WSBEiJ_G0022188
 protein coding gene Chr16:54645352-54785348 (+)



Homology
more
  • Human Ortholog
    SENP7, SUMO specific peptidase 7
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SENP7, SUMO specific peptidase 7
  • Links
    NCBI Gene ID: 57337
    neXtProt AC: NX_Q9BQF6
    UniProt: Q9BQF6

  • Chr Location
    3q12.3; chr3:101324205-101513241 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    7
  • cDNA Data
    20
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66315 NCBI Gene Model | MGI Sequence Detail 141089 C57BL/6J ±  kb
transcript NM_025483 RefSeq | MGI Sequence Detail 4908 C57BL/6  
polypeptide Q8BUH8 UniProt | EBI | MGI Sequence Detail 1037 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000014640 sentrin-specific protease 7
    (term hierarchy)
  • EC
    3.4.22.-
  • InterPro Domains
    IPR038765 Papain-like cysteine peptidase superfamily
    IPR051947 Sentrin-specific protease
    IPR003653 Ulp1 protease family, C-terminal catalytic domain
  • GlyGen
    Q8BUH8 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 20
    cDNA 20

    Microarray probesets 6
Other
Accession IDs
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MGI:1920119, MGI:1924062, MGI:1924964, MGI:2146486
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:357981 Pei J, et al., Senp7 deficiency impairs lipid droplets maturation in white adipose tissues via Plin4 deSUMOylation. J Biol Chem. 2024 Apr 25;300(6):107319
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory