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Tab1 Gene Detail
Summary
  • Symbol
    Tab1
  • Name
    TGF-beta activated kinase 1/MAP3K7 binding protein 1
  • Synonyms
    2310012M03Rik, b2b449Clo, Map3k7ip1, Tak1-binding protein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913763
    NCBI Gene: 66513
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:80017333-80045908 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.85 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    870 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913763
 protein coding gene Chr15:80017328-80045908 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022094
 protein coding gene Chr15:80449965-80483139 (+)
A/J MGP_AJ_G0022055
 protein coding gene Chr15:77665139-77694192 (+)
AKR/J MGP_AKRJ_G0022030
 protein coding gene Chr15:79832486-79861079 (+)
BALB/cJ MGP_BALBcJ_G0022061
 protein coding gene Chr15:77672849-77701775 (+)
C3H/HeJ MGP_C3HHeJ_G0021832
 protein coding gene Chr15:79825962-79857440 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022504
 protein coding gene Chr15:83615198-83646639 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020034
 protein coding gene Chr15:74144474-74174627 (+)
CAST/EiJ MGP_CASTEiJ_G0021353
 protein coding gene Chr15:80542467-80571908 (+)
CBA/J MGP_CBAJ_G0021797
 protein coding gene Chr15:86267492-86298583 (+)
DBA/2J MGP_DBA2J_G0021926
 protein coding gene Chr15:77157311-77185876 (+)
FVB/NJ MGP_FVBNJ_G0021904
 protein coding gene Chr15:76177561-76206314 (+)
LP/J MGP_LPJ_G0021994
 protein coding gene Chr15:80630612-80662396 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021924
 protein coding gene Chr15:91290261-91319825 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022518
 protein coding gene Chr15:79868830-79898433 (+)
PWK/PhJ MGP_PWKPhJ_G0021095
 protein coding gene Chr15:77167697-77197062 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020932
 protein coding gene Chr15:79670694-79699678 (+)
WSB/EiJ MGP_WSBEiJ_G0021405
 protein coding gene Chr15:80273920-80304239 (+)



Homology
more
  • Human Ortholog
    TAB1, TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAB1, TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  • Synonyms
    3'-Tab1, MAP3K7IP1
  • Links
    NCBI Gene ID: 10454
    neXtProt AC: NX_Q15750
    UniProt: Q15750

  • Chr Location
    22q13.1; chr22:39399778-39437132 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 4 alleles in 4 genetic backgrounds
    21 images
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant fetuses exhibit edema, hemorrhaging, cardiovascular and pulmonary dysmorphogenesis, and die in the late stages of gestation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    734
  • Tissues
    16
  • cDNA Data
    37
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66513 NCBI Gene Model | MGI Sequence Detail 28576 C57BL/6J ±  kb
    transcript NM_025609 RefSeq | MGI Sequence Detail 2960 C57BL/6  
    polypeptide Q8CF89 UniProt | EBI | MGI Sequence Detail 502 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 37

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:5314038
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 14
      Phenotypes 40
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:345487 Zhang J, et al., E3 ligase RNF99 negatively regulates TLR-mediated inflammatory immune response via K48-linked ubiquitination of TAB2. Cell Death Differ. 2023 Apr;30(4):966-978
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory