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Trim13 Gene Detail
Summary
  • Symbol
    Trim13
  • Name
    tripartite motif-containing 13
  • Synonyms
    3110001L12Rik, LEU5, Rfp2, RNF77
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913847
    NCBI Gene: 66597
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:61835696-61843395 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 33.16 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    207 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913847
 protein coding gene Chr14:61835675-61847736 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J MGP_AKRJ_G0021377
 protein coding gene Chr14:56715020-56722707 (+)
BALB/cJ MGP_BALBcJ_G0021407
 protein coding gene Chr14:54721499-54728703 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0021846
 protein coding gene Chr14:58712042-58719762 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019386
 protein coding gene Chr14:52738751-52746550 (+)
CAST/EiJ MGP_CASTEiJ_G0020701
 protein coding gene Chr14:52746541-52756001 (+)
CBA/J MGP_CBAJ_G0019380
 protein coding gene Chr12:31252644-31253537 (+)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0021253
 protein coding gene Chr14:53850441-53857647 (+)
LP/J MGP_LPJ_G0021349
 protein coding gene Chr14:57019282-57028468 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021282
 protein coding gene Chr14:59707379-59716825 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021869
 protein coding gene Chr14:55864390-55872116 (+)
PWK/PhJ MGP_PWKPhJ_G0020445
 protein coding gene Chr14:51095743-51104305 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020278
 protein coding gene Chr14:51791228-51799520 (+)
WSB/EiJ MGP_WSBEiJ_G0020754
 protein coding gene Chr14:56182900-56191461 (+)



Homology
more
  • Human Ortholog
    TRIM13, tripartite motif containing 13
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRIM13, tripartite motif containing 13
  • Synonyms
    CAR, DLEU5, LEU5, RFP2, RNF77
  • Links
    NCBI Gene ID: 10206
    neXtProt AC: NX_O60858
    UniProt: O60858

  • Chr Location
    13q14.2; chr13:49995888-50020481 (+)  GRCh38
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased lethality induced by EMCV infection and altered type I IFN production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    785
  • Tissues
    50
  • cDNA Data
    26
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035235 Ensembl Gene Model | MGI Sequence Detail 7700 C57BL/6J ±  kb
    transcript ENSMUST00000039562 Ensembl | MGI Sequence Detail 1550 Not Applicable  
    polypeptide ENSMUSP00000045009 Ensembl | MGI Sequence Detail 407 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 1
      cDNA 26
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 7
      Diseases 2
      Gene Ontology 7
      Phenotypes 21
    • Earliest
      J:66949 Kapanadze B, et al., Comparative sequence analysis of a region on human chromosome 13q14, frequently deleted in b-cell chronic lymphocytic leukemia, and its homologous region on mouse chromosome 14. Genomics. 2000 Dec 15;70(3):327-34
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory