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Atg4b Gene Detail
Summary
  • Symbol
    Atg4b
  • Name
    autophagy related 4B, cysteine peptidase
  • Synonyms
    2510009N07Rik, Apg4b, autophagin 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913865
    NCBI Gene: 66615
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:93682627-93717328 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 47.32 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    772 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913865
 protein coding gene Chr1:93679222-93718332 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016348
 protein coding gene Chr1:95393054-95433558 (+)
A/J MGP_AJ_G0016329
 protein coding gene Chr1:91978670-92021730 (+)
AKR/J MGP_AKRJ_G0016290
 protein coding gene Chr1:94689069-94733551 (+)
BALB/cJ MGP_BALBcJ_G0016285
 protein coding gene Chr1:92155580-92202613 (+)
C3H/HeJ MGP_C3HHeJ_G0016114
 protein coding gene Chr1:94948960-94991097 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016744
 protein coding gene Chr1:99014875-99059421 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014462
 protein coding gene Chr1:86220036-86262159 (+)
CAST/EiJ MGP_CASTEiJ_G0015697
 protein coding gene Chr1:94283244-94322891 (+)
CBA/J MGP_CBAJ_G0016088
 protein coding gene Chr1:102227022-102277734 (+)
DBA/2J MGP_DBA2J_G0016193
 protein coding gene Chr1:91182823-91222358 (+)
FVB/NJ MGP_FVBNJ_G0016192
 protein coding gene Chr1:90243560-90284315 (+)
LP/J MGP_LPJ_G0016264
 protein coding gene Chr1:96574263-96616057 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016217
 protein coding gene Chr1:105312504-105359519 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016783
 protein coding gene Chr1:94719380-94765753 (+)
PWK/PhJ MGP_PWKPhJ_G0015482
 protein coding gene Chr1:90610148-90651743 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015266
 protein coding gene Chr1:93655563-93704421 (+)
WSB/EiJ MGP_WSBEiJ_G0015757
 protein coding gene Chr1:94539921-94582044 (+)



Homology
more
  • Human Ortholog
    ATG4B, autophagy related 4B cysteine peptidase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATG4B, autophagy related 4B cysteine peptidase
  • Synonyms
    APG4B, AUTL1, HsAPG4B
  • Links
    NCBI Gene ID: 23192
    neXtProt AC: NX_Q9Y4P1
    UniProt: Q9Y4P1

  • Chr Location
    2q37.3; chr2:241637213-241673857 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 3 alleles in 3 genetic backgrounds
    2 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit decreased autophagy, impaired swimming, circling, head tilting, and abnormal utricle, saccular, and otolith morphology. Mice homozygous for another gene trap allele exhibit partial preweaning lethality and impaired motor coordination and learning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    785
  • Tissues
    46
  • cDNA Data
    13
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66615 NCBI Gene Model | MGI Sequence Detail 34702 C57BL/6J ±  kb
    transcript NM_174874 RefSeq | MGI Sequence Detail 3169 C57BL/6  
    polypeptide Q8BGE6 UniProt | EBI | MGI Sequence Detail 393 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2138547
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 5
      Gene Ontology 13
      Phenotypes 30
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:357803 Torres P, et al., TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic splicing inhibition. Acta Neuropathol. 2024 Sep 21;148(1):45
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory