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Eef1d Gene Detail
Summary
  • Symbol
    Eef1d
  • Name
    eukaryotic translation elongation factor 1 delta
  • Synonyms
    1700026P12Rik, 5730529A16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913906
    NCBI Gene: 66656
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:75766643-75781425 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 35.05 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    346 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913906
 protein coding gene Chr15:75766054-75781425 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021963
 protein coding gene Chr15:75942330-75957413 (-)
A/J MGP_AJ_G0021921
 protein coding gene Chr15:73176729-73191489 (-)
AKR/J MGP_AKRJ_G0021904
 protein coding gene Chr15:75155547-75170307 (-)
BALB/cJ MGP_BALBcJ_G0021930
 protein coding gene Chr15:73197487-73212247 (-)
C3H/HeJ MGP_C3HHeJ_G0021702
 protein coding gene Chr15:75216553-75231307 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022370
 protein coding gene Chr15:78780879-78795639 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019901
 protein coding gene Chr15:69849335-69864404 (-)
CAST/EiJ MGP_CASTEiJ_G0021221
 protein coding gene Chr15:75999461-76014235 (-)
CBA/J MGP_CBAJ_G0021669
 protein coding gene Chr15:81295367-81310127 (-)
DBA/2J MGP_DBA2J_G0021794
 protein coding gene Chr15:72707492-72722557 (-)
FVB/NJ MGP_FVBNJ_G0021775
 protein coding gene Chr15:71757758-71772775 (-)
LP/J MGP_LPJ_G0021865
 protein coding gene Chr15:76024101-76038859 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021799
 protein coding gene Chr15:86598678-86613480 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022390
 protein coding gene Chr15:75400163-75414925 (-)
PWK/PhJ MGP_PWKPhJ_G0020962
 protein coding gene Chr15:72843291-72859381 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020801
 protein coding gene Chr15:75130060-75144627 (-)
WSB/EiJ MGP_WSBEiJ_G0021273
 protein coding gene Chr15:75487470-75502232 (-)



Homology
more
  • Human Ortholog
    EEF1D, eukaryotic translation elongation factor 1 delta
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EEF1D, eukaryotic translation elongation factor 1 delta
  • Synonyms
    EF-1D, EF1D, FP1047
  • Links
    NCBI Gene ID: 1936
    neXtProt AC: NX_P29692
    UniProt: P29692

  • Chr Location
    8q24.3; chr8:143579697-143599541 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 2 alleles in 2 genetic backgrounds
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a selective deletion of the long isoform exhibit severe audiogenic seizures and show hypoactivity, decreased brain weight, hippocampus and midbrain atrophy, a thin cerebral cortex as well as increased protein synthesis and reticulum stress in response to aversive stimuli.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    2
  • cDNA Data
    215
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66656 NCBI Gene Model | MGI Sequence Detail 14783 C57BL/6J ±  kb
    transcript NM_029663 RefSeq | MGI Sequence Detail 2819 C57BL/6  
    polypeptide P57776 UniProt | EBI | MGI Sequence Detail 281 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      15 Sequences
    • InterPro Domains
      IPR018940 Elongation factor 1 beta central acidic region, eukaryote
      IPR036219 Translation elongation factor eEF-1beta-like superfamily
      IPR001326 Translation elongation factor EF1B, beta/delta chains, conserved site
      IPR049720 Translation elongation factor EF1B, beta/delta subunit
      IPR014038 Translation elongation factor EF1B, beta/delta subunit, guanine nucleotide exchange domain
      IPR014717 Translation elongation factor EF1B/small ribosomal subunit protein bS6
    • GlyGen
      P57776 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 215
      cDNA 215

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1923826, MGI:2144348
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 7
      Phenotypes 37
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory