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Gapvd1 Gene Detail
Summary
  • Symbol
    Gapvd1
  • Name
    GTPase activating protein and VPS9 domains 1
  • Synonyms
    2010005B09Rik, 4432404J10Rik, mKIAA1521
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913941
    NCBI Gene: 66691
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:34566190-34645297 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 22.87 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1502 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913941
 protein coding gene Chr2:34564606-34645297 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025639
 protein coding gene Chr2:33280936-33362775 (-)
A/J MGP_AJ_G0025616
 protein coding gene Chr2:31861673-31946080 (-)
AKR/J MGP_AKRJ_G0025586
 protein coding gene Chr2:32985229-33074785 (-)
BALB/cJ MGP_BALBcJ_G0025613
 protein coding gene Chr2:31967730-32055291 (-)
C3H/HeJ MGP_C3HHeJ_G0025373
 protein coding gene Chr2:32874841-32962906 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026057
 protein coding gene Chr2:34237548-34329519 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023466
 protein coding gene Chr2:30565678-30644767 (-)
CAST/EiJ MGP_CASTEiJ_G0024835
 protein coding gene Chr2:32867402-32959112 (-)
CBA/J MGP_CBAJ_G0025351
 protein coding gene Chr2:35566073-35662026 (-)
DBA/2J MGP_DBA2J_G0025484
 protein coding gene Chr2:31635292-31718317 (-)
FVB/NJ MGP_FVBNJ_G0025446
 protein coding gene Chr2:31524506-31609344 (-)
LP/J MGP_LPJ_G0025570
 protein coding gene Chr2:33185719-33275332 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025477
 protein coding gene Chr2:35077749-35177249 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026115
 protein coding gene Chr2:32877714-32964015 (-)
PWK/PhJ MGP_PWKPhJ_G0024583
 protein coding gene Chr2:31544664-31630349 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024383
 protein coding gene Chr2:33035351-33124558 (-)
WSB/EiJ MGP_WSBEiJ_G0024904
 protein coding gene Chr2:33051661-33139443 (-)



Homology
more
  • Human Ortholog
    GAPVD1, GTPase activating protein and VPS9 domains 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GAPVD1, GTPase activating protein and VPS9 domains 1
  • Synonyms
    GAPex-5, GAPEX5, RAP6
  • Links
    NCBI Gene ID: 26130
    neXtProt AC: NX_Q14C86
    UniProt: Q14C86

  • Chr Location
    9q33.3; chr9:125261794-125367207 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    20
  • cDNA Data
    15
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66691 NCBI Gene Model | MGI Sequence Detail 79108 C57BL/6J ±  kb
    transcript NM_001356441 RefSeq | MGI Sequence Detail 6811 C57BL/6  
    polypeptide Q6PAR5 UniProt | EBI | MGI Sequence Detail 1458 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1917078, MGI:2139305
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 9
    • Earliest
      J:65653 Wertz K, et al., Large-scale screen for genes involved in gonad development. Mech Dev. 2000 Nov;98(1-2):51-70
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory