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Chmp3 Gene Detail
Summary
  • Symbol
    Chmp3
  • Name
    charged multivesicular body protein 3
  • Synonyms
    25.1, 4921505F14Rik, 9130011K15Rik, CGI-49, D6Ertd286e, Vps24
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913950
    NCBI Gene: 66700
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:71520820-71559593 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 32.17 cM, cytoband C3
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    783 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913950
 protein coding gene Chr6:71520781-71559593 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030860
 protein coding gene Chr6:72027069-72068257 (+)
A/J MGP_AJ_G0030830
 protein coding gene Chr6:69256237-69295024 (+)
AKR/J MGP_AKRJ_G0030759
 protein coding gene Chr6:71269366-71303479 (+)
BALB/cJ MGP_BALBcJ_G0030841
 protein coding gene Chr6:69290908-69329804 (+)
C3H/HeJ MGP_C3HHeJ_G0030871
 protein coding gene Chr6:112947110-112984986 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031299
 protein coding gene Chr6:73926580-73973715 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028488
 protein coding gene Chr6:68446324-68481531 (+)
CAST/EiJ MGP_CASTEiJ_G0029949
 protein coding gene Chr6:71113729-71157935 (+)
CBA/J MGP_CBAJ_G0030528
 protein coding gene Chr6:76876443-76921291 (+)
DBA/2J MGP_DBA2J_G0030680
 protein coding gene Chr6:68642540-68681499 (+)
FVB/NJ MGP_FVBNJ_G0030633
 protein coding gene Chr6:68000700-68038561 (+)
LP/J MGP_LPJ_G0030759
 protein coding gene Chr6:71953013-71991740 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030668
 protein coding gene Chr6:80363679-80399973 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031325
 protein coding gene Chr6:71092084-71133747 (+)
PWK/PhJ MGP_PWKPhJ_G0029665
 protein coding gene Chr6:67519225-67557449 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029493
 protein coding gene Chr6:69792252-69856007 (+)
WSB/EiJ MGP_WSBEiJ_G0030031
 protein coding gene Chr6:71442312-71487835 (+)



Homology
more
  • Human Ortholog
    CHMP3, charged multivesicular body protein 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHMP3, charged multivesicular body protein 3
  • Synonyms
    CGI-149, NEDF, VPS24
  • Links
    NCBI Gene ID: 51652
    neXtProt AC: NX_Q9Y3E7
    UniProt: Q9Y3E7

  • Chr Location
    2p11.2; chr2:86503430-86563479 (-)  GRCh38
  • Human Ortholog
    RNF103-CHMP3, RNF103-CHMP3 readthrough
  • Synonyms
    CGI149, CHMP3, hVps24, NEDF, RNF103-VPS24, VPS24
  • Links
    NCBI Gene ID: 100526767
    neXtProt AC: NX_Q9Y3E7

  • Chr Location
    2p11.2; chr2:86503430-86721122 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    67
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    11
  • cDNA Data
    137
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66700 NCBI Gene Model | MGI Sequence Detail 38774 C57BL/6J ±  kb
    transcript NM_001355674 RefSeq | MGI Sequence Detail 2722 ZRU/MplStud  
    polypeptide Q9CQ10 UniProt | EBI | MGI Sequence Detail 224 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 139
      cDNA 137
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1098712, MGI:1914070
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory