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Duoxa2 Gene Detail
Summary
  • Symbol
    Duoxa2
  • Name
    dual oxidase maturation factor 2
  • Synonyms
    9030623N16Rik, Nip2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914061
    NCBI Gene: 66811
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:122129381-122133088 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 60.62 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    166 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914061
 protein coding gene Chr2:122129381-122133366 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026411
 protein coding gene Chr2:125300597-125304578 (+)
A/J MGP_AJ_G0026373
 protein coding gene Chr2:120174981-120179015 (+)
AKR/J MGP_AKRJ_G0026350
 protein coding gene Chr2:123541488-123545523 (+)
BALB/cJ MGP_BALBcJ_G0026385
 protein coding gene Chr2:120404663-120408697 (+)
C3H/HeJ MGP_C3HHeJ_G0026130
 protein coding gene Chr2:124023824-124027858 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026832
 protein coding gene Chr2:129366877-129370863 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024211
 protein coding gene Chr2:115144918-115148891 (+)
CAST/EiJ MGP_CASTEiJ_G0025592
 protein coding gene Chr2:124365068-124369045 (+)
CBA/J MGP_CBAJ_G0026109
 protein coding gene Chr2:133917196-133921230 (+)
DBA/2J MGP_DBA2J_G0026246
 protein coding gene Chr2:119571320-119575354 (+)
FVB/NJ MGP_FVBNJ_G0026208
 protein coding gene Chr2:118364287-118368264 (+)
LP/J MGP_LPJ_G0026348
 protein coding gene Chr2:125545850-125549856 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026228
 protein coding gene Chr2:138127791-138131766 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026887
 protein coding gene Chr2:123658720-123662757 (+)
PWK/PhJ MGP_PWKPhJ_G0025328
 protein coding gene Chr2:119185040-119189057 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025128
 protein coding gene Chr2:122801874-122805910 (+)
WSB/EiJ MGP_WSBEiJ_G0025664
 protein coding gene Chr2:124519698-124523668 (+)



Homology
more
  • Human Ortholog
    DUOXA2, dual oxidase maturation factor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DUOXA2, dual oxidase maturation factor 2
  • Synonyms
    SIMNIPHOM, TDH5
  • Links
    NCBI Gene ID: 405753
    neXtProt AC: NX_Q1HG44
    UniProt: Q1HG44

  • Chr Location
    15q21.1; chr15:45114326-45118421 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DUOXA2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    78 phenotypes from 1 allele in 1 genetic background
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele of Duoxa1 and 2 exhibit severe hypothyrodism with severe postnatal growth, delayed eye opening, enlarged thyroid, enlarged adenohypophysis, respiratory distress and death at weaning when weaned at 21 days.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    717
  • Tissues
    11
  • cDNA Data
    7
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66811 NCBI Gene Model | MGI Sequence Detail 3708 C57BL/6J ±  kb
    transcript NM_025777 RefSeq | MGI Sequence Detail 1314 C57BL/6  
    polypeptide Q9D311 UniProt | EBI | MGI Sequence Detail 320 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 7
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 2
      Gene Ontology 8
      Phenotypes 26
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory