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Rpl11 Gene Detail
Summary
  • Symbol
    Rpl11
  • Name
    ribosomal protein L11
  • Synonyms
    2010203J19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914275
    NCBI Gene: 67025
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:135776665-135780704 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 68.34 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    274 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914275
 protein coding gene Chr4:135755576-135780739 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028959
 protein coding gene Chr4:138530318-138562578 (-)
A/J MGP_AJ_G0028918
 protein coding gene Chr4:132648589-132673317 (-)
AKR/J MGP_AKRJ_G0028870
 protein coding gene Chr4:136484629-136511619 (-)
BALB/cJ MGP_BALBcJ_G0028942
 protein coding gene Chr4:133319926-133346054 (-)
C3H/HeJ MGP_C3HHeJ_G0028656
 protein coding gene Chr4:136760092-136790456 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029383
 protein coding gene Chr4:143443280-143483464 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026654
 protein coding gene Chr4:125696592-125722655 (-)
CAST/EiJ MGP_CASTEiJ_G0028088
 protein coding gene Chr4:134898424-134928367 (-)
CBA/J MGP_CBAJ_G0028621
 protein coding gene Chr4:147388504-147420447 (-)
DBA/2J MGP_DBA2J_G0028770
 protein coding gene Chr4:133077961-133103905 (-)
FVB/NJ MGP_FVBNJ_G0028737
 protein coding gene Chr4:132003968-132030431 (-)
LP/J MGP_LPJ_G0028869
 protein coding gene Chr4:138626848-138658233 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028763
 protein coding gene Chr4:151654091-151679862 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029421
 protein coding gene Chr4:136934598-136967919 (-)
PWK/PhJ MGP_PWKPhJ_G0027808
 protein coding gene Chr4:129845449-129871259 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027634
 protein coding gene Chr4:132752657-132782498 (-)
WSB/EiJ MGP_WSBEiJ_G0028166
 protein coding gene Chr4:137109636-137142751 (-)



Homology
more
  • Human Ortholog
    RPL11, ribosomal protein L11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPL11, ribosomal protein L11
  • Synonyms
    DBA7, GIG34, L11, uL5
  • Links
    NCBI Gene ID: 6135
    neXtProt AC: NX_P62913
    UniProt: P62913

  • Chr Location
    1p36.11; chr1:23691742-23696835 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Rpl11 mouse models; 2 with human RPL11 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    3
  • cDNA Data
    17
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67025 NCBI Gene Model | MGI Sequence Detail 4040 C57BL/6J ±  kb
    transcript NM_025919 RefSeq | MGI Sequence Detail 1231 C57BL/6  
    polypeptide Q9CXW4 UniProt | EBI | MGI Sequence Detail 178 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000014190 eukaryotic-type large ribosomal subunit protein uL5
      (term hierarchy)
    • PDB
      6SWA, 7CPU, 7CPV, 7LS1, 7LS2
    • InterPro Domains
      IPR002132 Large ribosomal subunit protein uL5
      IPR020929 Large ribosomal subunit protein uL5, conserved site
      IPR031309 Large ribosomal subunit protein uL5, C-terminal
      IPR022803 Large ribosomal subunit protein uL5 domain superfamily
      IPR031310 Large ribosomal subunit protein uL5, N-terminal
    • GlyGen
      Q9CXW4 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Primer pair 1

      Microarray probesets 8
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 13
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:333015 Li H, et al., A male germ-cell-specific ribosome controls male fertility. Nature. 2022 Dec;612(7941):725-731
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory