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Trak1 Gene Detail
Summary
  • Symbol
    Trak1
  • Name
    trafficking protein, kinesin binding 1
  • Synonyms
    2310001H13Rik, hyrt, nm1952
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914345
    NCBI Gene: 67095
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:121126568-121303984 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 72.41 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5021 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914345
 protein coding gene Chr9:121126568-121303985 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035441
 protein coding gene Chr9:124306305-124411063 (+)
A/J MGP_AJ_G0035422
 protein coding gene Chr9:119568536-119675585 (+)
AKR/J MGP_AKRJ_G0035355
 protein coding gene Chr9:122742311-122854425 (+)
BALB/cJ MGP_BALBcJ_G0035418
 protein coding gene Chr9:119479033-119584380 (+)
C3H/HeJ MGP_C3HHeJ_G0035125
 protein coding gene Chr9:123204621-123318157 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035941
 protein coding gene Chr9:127697084-127815234 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032823
 protein coding gene Chr9:116721709-116836300 (+)
CAST/EiJ MGP_CASTEiJ_G0034430
 protein coding gene Chr9:123247018-123354466 (+)
CBA/J MGP_CBAJ_G0035093
 protein coding gene Chr9:132372926-132496514 (+)
DBA/2J MGP_DBA2J_G0035252
 protein coding gene Chr9:119009741-119114392 (+)
FVB/NJ MGP_FVBNJ_G0035199
 protein coding gene Chr9:117930947-118035974 (+)
LP/J MGP_LPJ_G0035331
 protein coding gene Chr9:124633762-124748207 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035240
 protein coding gene Chr9:133337628-133453261 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035960
 protein coding gene Chr9:123192736-123304143 (+)
PWK/PhJ MGP_PWKPhJ_G0034134
 protein coding gene Chr9:119406866-119613757 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033970
 protein coding gene Chr9:123221493-123415416 (+)
WSB/EiJ MGP_WSBEiJ_G0034550
 protein coding gene Chr9:123040795-123148211 (+)



Homology
more
  • Human Ortholog
    TRAK1, trafficking kinesin protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TRAK1, trafficking kinesin protein 1
  • Synonyms
    DEE68, EIEE68, MILT1, OIP106
  • Links
    NCBI Gene ID: 22906
    neXtProt AC: NX_Q9UPV9
    UniProt: Q9UPV9

  • Chr Location
    3p22.1; chr3:42013093-42225890 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Trak1 mouse models; 1 with human TRAK1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with a spontaneous mutation in this allele have various behavioral abnormalities consistent with hypertonia. Inclusions can be found in neuronal processes of the gray matter of the brainstem and spinal cord.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    820
  • Tissues
    31
  • cDNA Data
    17
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032536 Ensembl Gene Model | MGI Sequence Detail 177417 C57BL/6J ±  kb
    transcript ENSMUST00000238988 Ensembl | MGI Sequence Detail 3353 Not Applicable  
    polypeptide ENSMUSP00000158925 Ensembl | MGI Sequence Detail 968 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 17

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2143032, MGI:2143074, MGI:3044766
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory