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Ctdnep1 Gene Detail
Summary
  • Symbol
    Ctdnep1
  • Name
    CTD nuclear envelope phosphatase 1
  • Synonyms
    2610507E10Rik, Dullard
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914431
    NCBI Gene: 67181
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69871994-69881427 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 42.95 cM, cytoband B4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    70 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914431
 protein coding gene Chr11:69871982-69881427 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018574
 protein coding gene Chr11:70474385-70484982 (+)
A/J MGP_AJ_G0018542
 protein coding gene Chr11:67806537-67815407 (+)
AKR/J MGP_AKRJ_G0018511
 protein coding gene Chr11:69827866-69836761 (+)
BALB/cJ MGP_BALBcJ_G0018514
 protein coding gene Chr11:68135063-68143950 (+)
C3H/HeJ MGP_C3HHeJ_G0018327
 protein coding gene Chr11:69865891-69874820 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018965
 protein coding gene Chr11:72597815-72607242 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016610
 protein coding gene Chr11:64730338-64739945 (+)
CAST/EiJ MGP_CASTEiJ_G0017882
 protein coding gene Chr11:70109734-70119560 (+)
CBA/J MGP_CBAJ_G0018299
 protein coding gene Chr11:75854377-75866605 (+)
DBA/2J MGP_DBA2J_G0018409
 protein coding gene Chr11:67391194-67399897 (+)
FVB/NJ MGP_FVBNJ_G0018399
 protein coding gene Chr11:67038667-67047363 (+)
LP/J MGP_LPJ_G0018479
 protein coding gene Chr11:71056538-71066109 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018422
 protein coding gene Chr11:76444786-76454786 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019007
 protein coding gene Chr11:70100686-70109594 (+)
PWK/PhJ MGP_PWKPhJ_G0017656
 protein coding gene Chr11:68042514-68051332 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017446
 protein coding gene Chr11:69918616-69927272 (+)
WSB/EiJ MGP_WSBEiJ_G0017936
 protein coding gene Chr11:69765026-69773722 (+)



Homology
more
  • Human Ortholog
    CTDNEP1, CTD nuclear envelope phosphatase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTDNEP1, CTD nuclear envelope phosphatase 1
  • Synonyms
    DULLARD, HSA011916, NET56
  • Links
    NCBI Gene ID: 23399
    neXtProt AC: NX_O95476
    UniProt: O95476

  • Chr Location
    17p13.1; chr17:7243591-7252491 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    3 images
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality, abnormal extraembryonic tissue development, poorly developed head fold and trunk and severely reduced primordial germ cell numbers due to a failure to transit to mesoderm.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    7
  • cDNA Data
    107
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67181 NCBI Gene Model | MGI Sequence Detail 9434 C57BL/6J ±  kb
    transcript NM_026017 RefSeq | MGI Sequence Detail 1615 C57BL/6  
    polypeptide Q3TP92 UniProt | EBI | MGI Sequence Detail 244 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 107
      cDNA 107

      Microarray probesets 3
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 20
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:333381 Luo Z, et al., Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability. Nat Commun. 2023 Feb 10;14(1):762
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory