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Dock7 Gene Detail
Summary
  • Symbol
    Dock7
  • Name
    dedicator of cytokinesis 7
  • Synonyms
    3110056M06Rik, LOC242555, m, mKIAA1771
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914549
    NCBI Gene: 67299
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:98824908-99009152 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 45.60 cM, cytoband C6
  • Mapping Data
    29 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5019 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914549
 protein coding gene Chr4:98824669-99019190 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028477
 protein coding gene Chr4:99135547-99342849 (-)
A/J MGP_AJ_G0028440
 protein coding gene Chr4:95695582-95885460 (-)
AKR/J MGP_AKRJ_G0028387
 protein coding gene Chr4:98013958-98213154 (-)
BALB/cJ MGP_BALBcJ_G0028458
 protein coding gene Chr4:95937498-96136439 (-)
C3H/HeJ MGP_C3HHeJ_G0028171
 protein coding gene Chr4:98808935-99009315 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028897
 protein coding gene Chr4:102904374-103108037 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026189
 protein coding gene Chr4:91076514-91273043 (-)
CAST/EiJ MGP_CASTEiJ_G0027611
 protein coding gene Chr4:96599374-96797230 (-)
CBA/J MGP_CBAJ_G0028140
 protein coding gene Chr4:106056588-106268320 (-)
DBA/2J MGP_DBA2J_G0028290
 protein coding gene Chr4:95431541-95616689 (-)
FVB/NJ MGP_FVBNJ_G0028257
 protein coding gene Chr4:94271536-94462080 (-)
LP/J MGP_LPJ_G0028390
 protein coding gene Chr4:99457430-99658544 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028285
 protein coding gene Chr4:111791802-112008946 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028935
 protein coding gene Chr4:98260579-98454659 (-)
PWK/PhJ MGP_PWKPhJ_G0027336
 protein coding gene Chr4:93571357-93760191 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027157
 protein coding gene Chr4:95706554-95905917 (-)
WSB/EiJ MGP_WSBEiJ_G0027689
 protein coding gene Chr4:98392851-98593807 (-)



Homology
more
  • Human Ortholog
    DOCK7, dedicator of cytokinesis 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DOCK7, dedicator of cytokinesis 7
  • Synonyms
    DEE23, EIEE23, ZIR2
  • Links
    NCBI Gene ID: 85440
    neXtProt AC: NX_Q96N67
    UniProt: Q96N67

  • Chr Location
    1p31.3; chr1:62454298-62688386 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Dock7 mouse models; 1 with human DOCK7 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    1 images
    97 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for mutations of this gene exhibit coat color dilution, white tail tip, and on some genetic backgrounds a white belly spot.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    791
  • Tissues
    51
  • cDNA Data
    151
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028556 Ensembl Gene Model | MGI Sequence Detail 184245 C57BL/6J ±  kb
    transcript ENSMUST00000127417 Ensembl | MGI Sequence Detail 6796 Not Applicable  
    polypeptide ENSMUSP00000117797 Ensembl | MGI Sequence Detail 2130 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 152
      cDNA 151
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12089, MGI:2685276, MGI:96903
    References
    more
    • Summaries
      All 161
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 12
      Phenotypes 97
    • Earliest
      J:12159 Woolley GW, "Misty," a new coat color dilution in the mouse, Mus musculus. Am Naturalist. 1941;75:507-508
    • Latest
      J:350675 Yu V, et al., Differential CpG methylation at Nnat in the early establishment of beta cell heterogeneity. Diabetologia. 2024 Jun;67(6):1079-1094
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory