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Prss3b Gene Detail
Summary
  • Symbol
    Prss3b
  • Name
    serine protease 3B
  • Synonyms
    2210010C04Rik, cationic trypsinogen (isoform T7), T7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914623
    NCBI Gene: 67373
  • Alliance
    gene page
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:41007202-41012443 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 19.10 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    207 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914623
 protein coding gene Chr6:41007202-41012443 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030621
 protein coding gene Chr6:39503805-39509046 (-)
A/J MGP_AJ_G0030596
 protein coding gene Chr6:37784113-37789354 (-)
AKR/J MGP_AKRJ_G0030523
 protein coding gene Chr6:38986332-38991573 (-)
BALB/cJ MGP_BALBcJ_G0030606
 protein coding gene Chr6:37994338-37999579 (-)
C3H/HeJ MGP_C3HHeJ_G0030319
 protein coding gene Chr6:39009150-39014391 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031060
 protein coding gene Chr6:40499304-40504545 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028272
 protein coding gene Chr6:35568898-35574718 (-)
CAST/EiJ MGP_CASTEiJ_G0029721
 protein coding gene Chr6:38899621-38904862 (-)
CBA/J MGP_CBAJ_G0030295
 protein coding gene Chr6:42126936-42132177 (-)
DBA/2J MGP_DBA2J_G0030441
 protein coding gene Chr6:37596120-37601361 (-)
FVB/NJ MGP_FVBNJ_G0030393
 protein coding gene Chr6:37369579-37374820 (-)
LP/J MGP_LPJ_G0030528
 protein coding gene Chr6:39519116-39524357 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030431
 protein coding gene Chr6:44369178-44374419 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031089
 protein coding gene Chr6:38949814-38955055 (-)
PWK/PhJ MGP_PWKPhJ_G0029435
 protein coding gene Chr6:37217077-37222312 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029271
 protein coding gene Chr6:38655533-38663348 (-)
WSB/EiJ MGP_WSBEiJ_G0029797
 protein coding gene Chr6:38891907-38897148 (-)



Homology
less
Human Diseases
more
  • Diseases
    1 with Prss3b mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an autoactivated allele are runted and die by 2 months of age. Mice heterozygous for the allele develop acute and chronic pancreatitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    722
  • Tissues
    6
  • cDNA Data
    291
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67373 NCBI Gene Model | MGI Sequence Detail 5242 C57BL/6J ±  kb
    transcript NM_023333 RefSeq | MGI Sequence Detail 2142 C57BL/6  
    polypeptide NP_075822 RefSeq | MGI Sequence Detail 247 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR001314 Peptidase S1A, chymotrypsin family
      IPR009003 Peptidase S1, PA clan
      IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
      IPR050127 Serine Proteases (Peptidase S1 Family)
      IPR001254 Serine proteases, trypsin domain
      IPR018114 Serine proteases, trypsin family, histidine active site
      IPR033116 Serine proteases, trypsin family, serine active site
    • GlyGen
      Q9CPN9 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 291
      cDNA 291

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2141617, MGI:7388428
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 4
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory