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Sf3a1 Gene Detail
Summary
  • Symbol
    Sf3a1
  • Name
    splicing factor 3a, subunit 1
  • Synonyms
    1200014H24Rik, 5930416L09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914715
    NCBI Gene: 67465
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:4110354-4132541 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 2.91 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    520 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914715
 protein coding gene Chr11:4110350-4132541 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017977
 protein coding gene Chr11:1090363-1113320 (+)
A/J MGP_AJ_G0017950
 protein coding gene Chr11:1103564-1125737 (+)
AKR/J MGP_AKRJ_G0017914
 protein coding gene Chr11:1159232-1181417 (+)
BALB/cJ MGP_BALBcJ_G0017918
 protein coding gene Chr11:1072701-1094884 (+)
C3H/HeJ MGP_C3HHeJ_G0017731
 protein coding gene Chr11:1052208-1074356 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018371
 protein coding gene Chr11:1173338-1195515 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016029
 protein coding gene Chr11:981859-1006034 (+)
CAST/EiJ MGP_CASTEiJ_G0017293
 protein coding gene Chr11:1018503-1040844 (+)
CBA/J MGP_CBAJ_G0017706
 protein coding gene Chr11:1414862-1437868 (+)
DBA/2J MGP_DBA2J_G0017817
 protein coding gene Chr11:1007239-1029430 (+)
FVB/NJ MGP_FVBNJ_G0017808
 protein coding gene Chr11:1041165-1063337 (+)
LP/J MGP_LPJ_G0017887
 protein coding gene Chr11:1197990-1220164 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017834
 protein coding gene Chr11:1085958-1109195 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018410
 protein coding gene Chr11:1165706-1188981 (+)
PWK/PhJ MGP_PWKPhJ_G0017074
 protein coding gene Chr11:1010761-1033159 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016870
 protein coding gene Chr11:1114460-1143921 (+)
WSB/EiJ MGP_WSBEiJ_G0017347
 protein coding gene Chr11:1030295-1052491 (+)



Homology
more
  • Human Ortholog
    SF3A1, splicing factor 3a subunit 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SF3A1, splicing factor 3a subunit 1
  • Synonyms
    PRP21, PRPF21, SAP114, SF3A120
  • Links
    NCBI Gene ID: 10291
    neXtProt AC: NX_Q15459
    UniProt: Q15459

  • Chr Location
    22q12.2; chr22:30331988-30356919 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption may exhibit preimplantation lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    22
  • cDNA Data
    277
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 67465 NCBI Gene Model | MGI Sequence Detail 22188 C57BL/6J ±  kb
transcript NM_026175 RefSeq | MGI Sequence Detail 4916 C57BL/6  
polypeptide Q8K4Z5 UniProt | EBI | MGI Sequence Detail 791 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 279
    cDNA 278
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1924358, MGI:2144075
References
more
  • Summaries
    All 35
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:355635 Diaz-Hernandez JI, et al., Age-related nuclear translocation of P2X6 subunit modifies splicing activity interacting with splicing factor 3A1. PLoS One. 2015;10(4):e0123121
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory