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Ciao3 Gene Detail
Summary
  • Symbol
    Ciao3
  • Name
    cytosolic iron-sulfur assembly component 3
  • Synonyms
    9030612I22Rik, Narfl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914813
    NCBI Gene: 67563
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:25992750-26002306 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.88 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    273 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914813
 protein coding gene Chr17:25992750-26002306 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023365
 protein coding gene Chr17:24868577-24879425 (+)
A/J MGP_AJ_G0023324
 protein coding gene Chr17:24146573-24156146 (+)
AKR/J MGP_AKRJ_G0023290
 protein coding gene Chr17:24249789-24260198 (+)
BALB/cJ MGP_BALBcJ_G0023329
 protein coding gene Chr17:24371560-24381780 (+)
C3H/HeJ MGP_C3HHeJ_G0023089
 protein coding gene Chr17:24634327-24643720 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023771
 protein coding gene Chr17:25920939-25932340 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021247
 protein coding gene Chr17:21607497-21617293 (+)
CAST/EiJ MGP_CASTEiJ_G0022591
 protein coding gene Chr17:24514829-24527837 (+)
CBA/J MGP_CBAJ_G0023064
 protein coding gene Chr17:26830228-26839685 (+)
DBA/2J MGP_DBA2J_G0023194
 protein coding gene Chr17:23747237-23756731 (+)
FVB/NJ MGP_FVBNJ_G0023164
 protein coding gene Chr17:23487128-23497385 (+)
LP/J MGP_LPJ_G0023271
 protein coding gene Chr17:25166848-25177155 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023183
 protein coding gene Chr17:26446001-26455422 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023811
 protein coding gene Chr17:24569655-24581059 (+)
PWK/PhJ MGP_PWKPhJ_G0022340
 protein coding gene Chr17:22509006-22519730 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022158
 protein coding gene Chr17:22643524-22653081 (+)
WSB/EiJ MGP_WSBEiJ_G0022654
 protein coding gene Chr17:24622546-24631994 (+)



Homology
more
  • Human Ortholog
    CIAO3, cytosolic iron-sulfur assembly component 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CIAO3, cytosolic iron-sulfur assembly component 3
  • Synonyms
    HPRN, IOP1, LET1L, NAR1, NARFL, PRN
  • Links
    NCBI Gene ID: 64428
    neXtProt AC: NX_Q9H6Q4
    UniProt: Q9H6Q4

  • Chr Location
    16p13.3; chr16:729760-741329 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted knock-out die before E10.5. Mice heterozygous for a targeted allele exhibit partial lethality between E10.5 and birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    9
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67563 NCBI Gene Model | MGI Sequence Detail 9557 C57BL/6J ±  kb
transcript NM_026238 RefSeq | MGI Sequence Detail 2555 C57BL/6  
polypeptide Q7TMW6 UniProt | EBI | MGI Sequence Detail 476 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 9

    Microarray probesets 4
Other
Accession IDs
less
MGI:2146884, MGI:6286362
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory