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Gadd45gip1 Gene Detail
Summary
  • Symbol
    Gadd45gip1
  • Name
    growth arrest and DNA-damage-inducible, gamma interacting protein 1
  • Synonyms
    2310040G17Rik, Crif1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914947
    NCBI Gene: 102060
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:85558911-85562111 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 41.19 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    116 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914947
 protein coding gene Chr8:85558151-85562111 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033871
 protein coding gene Chr8:85755112-85759074 (+)
A/J MGP_AJ_G0033854
 protein coding gene Chr8:82375204-82379304 (+)
AKR/J MGP_AKRJ_G0033780
 protein coding gene Chr8:84814735-84818700 (+)
BALB/cJ MGP_BALBcJ_G0033847
 protein coding gene Chr8:82502042-82506007 (+)
C3H/HeJ MGP_C3HHeJ_G0033557
 protein coding gene Chr8:85437936-85443175 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034367
 protein coding gene Chr8:89036366-89040326 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031309
 protein coding gene Chr8:76166960-76170881 (+)
CAST/EiJ MGP_CASTEiJ_G0032887
 protein coding gene Chr8:84861955-84865922 (+)
CBA/J MGP_CBAJ_G0033533
 protein coding gene Chr8:92078168-92082347 (+)
DBA/2J MGP_DBA2J_G0033686
 protein coding gene Chr8:82014557-82018722 (+)
FVB/NJ MGP_FVBNJ_G0033634
 protein coding gene Chr8:80959839-80964108 (+)
LP/J MGP_LPJ_G0033778
 protein coding gene Chr8:85864185-85868147 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033676
 protein coding gene Chr8:94634049-94638049 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034384
 protein coding gene Chr8:84805249-84809209 (+)
PWK/PhJ MGP_PWKPhJ_G0032591
 protein coding gene Chr8:81261423-81265510 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032427
 protein coding gene Chr8:83614282-83618240 (+)
WSB/EiJ MGP_WSBEiJ_G0033000
 protein coding gene Chr8:85231965-85235927 (+)



Homology
more
  • Human Ortholog
    GADD45GIP1, GADD45G interacting protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GADD45GIP1, GADD45G interacting protein 1
  • Synonyms
    CKBBP2, CKbetaBP2, CRIF1, mL64, MRP-L59, PLINP, Plinp1, PLINP-1, PRG6
  • Links
    NCBI Gene ID: 90480
    neXtProt AC: NX_Q8TAE8
    UniProt: Q8TAE8

  • Chr Location
    19p13.13; chr19:12953119-12957223 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gadd45gip1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 2 alleles in 3 genetic backgrounds
    2 images
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display embryonic lethality before somite formation with decreased cell proliferation, increased apoptisis, and failure of inner cell mass outgrowth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    20
  • cDNA Data
    13
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 102060 NCBI Gene Model | MGI Sequence Detail 3201 C57BL/6J ±  kb
    transcript NM_183358 RefSeq | MGI Sequence Detail 1734 C57BL/6  
    polypeptide Q9CR59 UniProt | EBI | MGI Sequence Detail 222 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 13
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2142529
    References
    more
    • Summaries
      All 86
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 6
      Phenotypes 58
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:352379 Lee S, et al., CRIF1 deficiency induces FOXP3(LOW) inflammatory non-suppressive regulatory T cells, thereby promoting antitumor immunity. Sci Adv. 2024 Mar 29;10(13):eadj9600
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory