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Kirrel3 Gene Detail
Summary
  • Symbol
    Kirrel3
  • Name
    kirre like nephrin family adhesion molecule 3
  • Synonyms
    1500010O20Rik, 2900036G11Rik, mKIAA1867, Neph2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914953
    NCBI Gene: 67703
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:34397190-34948012 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 18.97 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    15167 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914953
 protein coding gene Chr9:34396850-34952103 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034527
 protein coding gene Chr9:32284363-32850620 (+)
A/J MGP_AJ_G0034505
 protein coding gene Chr9:31456951-32006980 (+)
AKR/J MGP_AKRJ_G0034431
 protein coding gene Chr9:32155128-32720669 (+)
BALB/cJ MGP_BALBcJ_G0034496
 protein coding gene Chr9:31364341-31922226 (+)
C3H/HeJ MGP_C3HHeJ_G0034208
 protein coding gene Chr9:32491074-33058640 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035017
 protein coding gene Chr9:33381285-33957004 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031947
 protein coding gene Chr9:30142533-30698104 (+)
CAST/EiJ MGP_CASTEiJ_G0033531
 protein coding gene Chr9:32368418-32949052 (+)
CBA/J MGP_CBAJ_G0034182
 protein coding gene Chr9:34497754-35104921 (+)
DBA/2J MGP_DBA2J_G0034339
 protein coding gene Chr9:31430296-31985009 (+)
FVB/NJ MGP_FVBNJ_G0034282
 protein coding gene Chr9:30846164-31401102 (+)
LP/J MGP_LPJ_G0034425
 protein coding gene Chr9:32518239-33100795 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034326
 protein coding gene Chr9:36118733-36687095 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035037
 protein coding gene Chr9:32110182-32677072 (+)
PWK/PhJ MGP_PWKPhJ_G0033236
 protein coding gene Chr9:31408941-31971716 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033071
 protein coding gene Chr9:32243088-32822674 (+)
WSB/EiJ MGP_WSBEiJ_G0033646
 protein coding gene Chr9:31868060-32445079 (+)



Homology
more
  • Human Ortholog
    KIRREL3, kirre like nephrin family adhesion molecule 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KIRREL3, kirre like nephrin family adhesion molecule 3
  • Synonyms
    KIRRE, MRD4, NEPH2, PRO4502
  • Links
    NCBI Gene ID: 84623
    neXtProt AC: NX_Q8IZU9
    UniProt: Q8IZU9

  • Chr Location
    11q24.2; chr11:126423358-127003460 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired accessory olfactory bulb formation with reduced coalescence of vomeronasal sensory neuron axons in the posterior accessory olfactory bulb, loss of male-male aggression and abnormal male sexual response to a male intruder mouse.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    827
  • Tissues
    92
  • cDNA Data
    14
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032036 Ensembl Gene Model | MGI Sequence Detail 550823 C57BL/6J ±  kb
    transcript ENSMUST00000187182 Ensembl | MGI Sequence Detail 3532 Not Applicable  
    polypeptide ENSMUSP00000140219 Ensembl | MGI Sequence Detail 777 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 15
      Primer pair 1
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1920101
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 16
      Gene Ontology 10
      Phenotypes 20
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:343585 Traenkner D, et al., Modular Splicing Is Linked to Evolution in the Synapse-Specificity Molecule Kirrel3. eNeuro. 2023 Dec;10(12):ENEURO.0253-23.2023
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory